• Structurally based on the Canadian Clinical Adult case definition,
• And have more required specific symptoms than the (Fukuda et al. Ann Intern Med 121:953-959, 1994) adult case definition.
Physicians specializing in pediatric ME/CFS referred 33 pediatric patients with ME/CFS and 21 youth without the illness. Those who met ME/CFS criteria were separated into Severe and Moderate categories.
Significant differences were found for symptoms within each of the six major categories:
– Post-exertional malaise,
– Neurocognitive difficulties,
– And autonomic/neuroendocrine/immune manifestations.
In general, the results showed
• Participants who met the Severe ME/CFS criteria reported the highest scores,
• The Moderate ME/CFS group show scores that were a little lower,
• And the control group evidenced the lowest scores.
Findings indicate that the Pediatric Case Definition for ME/CFS can distinguish between those with this illness and controls, and between those with Severe versus Moderate manifestations of the illness.
Source: Child Psychiatry and Human Development, Jun 10, 2009. PMID: 19513826, by Jason L, Porter N, Shelleby E, Till L, Bell DS, Lapp CW, Rowe K, De Meirleir K. Center for Community Research, DePaul University, Chicago, Illinois; Medina Hospital, Lyndonville, New York; Hunter-Hopkins Center, Charlotte, North Carolina, USA – and Royal Children’s Hospital, Herston, QLD, Australia; Vrije Universiteit Brussel, Brussel, Belgium. [E-mail: Ljason@depaul.edu]