Skeletal muscle abnormalities in patients with fibromyalgia (FM)

Widespread muscle pain and tender points are the most common

complaints of fibromyalgia patients, and the underlying

mechanisms responsible for these symptoms have been studied

intensively during the past decade. It has been suggested that

fatigue and pain may lead to decreased levels of physical

activity in many patients. The resulting deconditioned state

may itself contribute to muscle abnormalities. Associated

symptoms such as disturbed sleep, anxiety, depression, or

irritable bowel also may have a negative impact on muscle

function and level of daily activities. The important

interactions between the central nervous and musculoskeletal

systems may involve another element, the neuroendocrine

stress-response system. This review will consider both the

current state of knowledge and also future studies which might

be designed to answer more effectively the outstanding

questions regarding the underlying pathogenesis of


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