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Sleep, neuroimmune & neuroendocrine functions in fibromyalgia (FM) & Chronic Fatigue Syndrome (CFS)

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The justification for disordered chronobiology for fibromyalgia and
chronic fatigue syndrome (CFS) is based on the following
evidence: The studies on disordered sleep physiology and the
symptoms of fibromyalgia and CFS; the experimental studies
that draw a link between interleukin-1 (IL-1),
immune-neuroendocrine-thermal systems and the sleep-wake
cycle; studies and preliminary data of the inter-relationships
of sleep-wakefulness, IL-1, and aspects of peripheral immune
and neuroendocrine functions in healthy men and in women
during differing phases of the menstrual cycle; and the
observations of alterations in the immune-neuroendocrine
functions of patients with fibromyalgia and CFS (Moldofsky,
1993b, d). Time series analyses of measures of the circadian
pattern of the sleep-wake behavioural system, immune,
neuroendocrine and temperature functions in patients with
fibromyalgia and CFS should determine whether alterations of
aspects of the neuro-immune-endocrine systems that accompany
disordered sleep physiology result in nonrestorative sleep,
pain, fatigue, cognitive and mood symptoms in patients with
fibromyalgia and CFS.

Moldofsky H

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