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Somatomedin C (insulin-like growth factor 1) levels decrease during acute changes of stress related hormones. Relevance for fibromyalgia (FM)

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OBJECTIVE. To determine the effects of stress hormones on

insulin-like growth factor 1 (IGF-1).

METHODS. Insulin induced

hypoglycemia (< 3 mmol/l) and clonidine induced depression of

noradrenergic tone were used to assess the acute effects of

cortisol, human growth hormone (hGH), and norepinephrine (NE).

RESULTS. Despite the increase of hGH during hypoglycemia, a

statistically significant decrease of IGF-1 was observed along

with the expected rise of cortisol and NE. To eliminate the

role played by NE, NE tone was depressed by administering

clonidine. A statistically significant decrease of IGF-1 was

also observed.

CONCLUSION. Acute cortisol release or a NE

decrease induce low IGF-1 levels. {MCMStrSt}

Ferraccioli G, Guerra P, Rizzi V, Baraldo M, Salaffi F, Furlanut M,

Bartoli E

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