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Stanford Study Finds Brain Abnormalities in ME/CFS Patients

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Press Release: Eurekalert, October 29, 2014. An imaging study by Stanford University School of Medicine investigators has found distinct differences between the brains of patients with chronic fatigue syndrome and those of healthy people

The findings could lead to more definitive diagnoses of the syndrome and may also point to an underlying mechanism in the disease process.

It’s not uncommon for CFS patients to face several mischaracterizations of their condition, or even suspicions of hypochondria, before receiving a diagnosis of CFS. The abnormalities identified in the study, to be published Oct. 29 in Radiology, may help to resolve those ambiguities, said lead author Michael Zeineh, MD, PhD, assistant professor of radiology.

“Using a trio of sophisticated imaging methodologies, we found that CFS patients’ brains diverge from those of healthy subjects in at least three distinct ways,” Zeineh said.

CFS affects between 1 million and 4 million individuals in the United States and millions more worldwide. Coming up with a more precise number of cases is tough because it’s difficult to actually diagnose the disease. While all CFS patients share a common symptom — crushing, unremitting fatigue that persists for six months or longer — the additional symptoms can vary from one patient to the next, and they often overlap with those of other conditions.

Scientific Challenge

“CFS is one of the greatest scientific and medical challenges of our time,” said the study’s senior author, Jose Montoya, MD, professor of infectious diseases and geographic medicine. “Its symptoms often include not only overwhelming fatigue but also joint and muscle pain, incapacitating headaches, food intolerance, sore throat, enlargement of the lymph nodes, gastrointestinal problems, abnormal blood-pressure and heart-rate events, and hypersensitivity to light, noise or other sensations.”

The combination of symptoms can devastate a patient’s life for 10, 20 or even 30 years, said Montoya, who has been following 200 CFS patients for several years in an effort to identify the syndrome’s underlying mechanisms. He hopes to accelerate the development of more-effective treatments than now exist. (A new Stanford Medicine magazine story describes the study in more detail.)

“In addition to potentially providing the CFS-specific diagnostic biomarker we’ve been desperately seeking for decades, these findings hold the promise of identifying the area or areas of the brain where the disease has hijacked the central nervous system,” Montoya said.

“If you don’t understand the disease, you’re throwing darts blindfolded,” said Zeineh. “We asked ourselves whether brain imaging could turn up something concrete that differs between CFS patients’ and healthy people’s brains. And, interestingly, it did.”

The Stanford investigators compared brain images of 15 CFS patients chosen from the group Montoya has been following to those of 14 age- and sex-matched healthy volunteers with no history of fatigue or other conditions causing symptoms similar to those of CFS.

Three Key Findings

The analysis yielded three noteworthy results, the researchers said. First, an MRI showed that overall white-matter content of CFS patients’ brains, compared with that of healthy subjects’ brains, was reduced. The term “white matter” largely denotes the long, cablelike nerve tracts carrying signals among broadly dispersed concentrations of “gray matter.” The latter areas specialize in processing information, and the former in conveying the information from one part of the brain to another.

That finding wasn’t entirely unexpected, Zeineh said. CFS is thought to involve chronic inflammation, quite possibly as a protracted immunological response to an as-yet unspecified viral infection. Inflammation, meanwhile, is known to take a particular toll on white matter.

But a second finding was entirely unexpected. Using an advanced imaging technique — diffusion-tensor imaging, which is especially suited to assessing the integrity of white matter — Zeineh and his colleagues identified a consistent abnormality in a particular part of a nerve tract in the right hemisphere of CFS patients’ brains. This tract, which connects two parts of the brain called the frontal lobe and temporal lobe, is called the right arcuate fasciculus, and in CFS patients it assumed an abnormal appearance.

Furthermore, there was a fairly strong correlation between the degree of abnormality in a CFS patient’s right arcuate fasciculus and the severity of the patient’s condition, as assessed by performance on a standard psychometric test used to evaluate fatigue.

Right vs. Left

Although the right arcuate fasciculus’s function is still somewhat mysterious, its counterpart in the brain’s left hemisphere has been extensively explored. The left arcuate fasciculus connects two critical language areas of the left side of the brain termed Wernicke’s and Broca’s areas, which are gray-matter structures several centimeters apart. These two structures are important to understanding and generating speech, respectively. Right-handed people almost always have language organized in this fashion exclusively in the left side of the brain, but the precise side (left or right) and location of speech production and comprehension are not so clear-cut in left-handed people. (It’s sometimes said that every left-hander’s brain is a natural experiment.) So, pooling left- and right-handed people’s brain images can be misleading. And, sure enough, the finding of an abnormality in the right arcuate fasciculus, pronounced among right-handers, was murky until the two left-handed patients and four left-handed control subjects’ images were exempted from the analysis.

Bolstering these observations was the third finding: a thickening of the gray matter at the two areas of the brain connected by the right arcuate fasciculus in CFS patients, compared with controls. Its correspondence with the observed abnormality in the white matter joining them makes it unlikely that the two were chance findings, Zeineh said.

Although these results were quite robust, he said, they will need to be confirmed. “This study was a start,” he said. “It shows us where to look.” The Stanford scientists are in the planning stages of a substantially larger study.


Additional Stanford co-authors are former medical fellow James Kang, MD, now a neuroradiologist in Hawaii; former professor of radiology and chief of neuroradiology Scott Atlas, MD, now a senior fellow at the Stanford-affiliated Hoover Institution; professor of radiology and of psychiatry and behavioral sciences Allan Reiss, MD; lead scientific programmer Mira Raman; physician assistant Jane Norris; and social-science research assistant Ian Valencia.

The study was supported by GE Healthcare and by the CFS Fund, which is housed in the Stanford Department of Medicine’s Division of Infectious Diseases. Information about Stanford’s Department of Radiology, which also supported this work, is available HERE

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3 thoughts on “Stanford Study Finds Brain Abnormalities in ME/CFS Patients”

  1. nilagold says:

    I can only speak for my brain.. Ha Ha…How can I do that when the left isn’t talking to the right? Ha Ha.. I’ve had CFIDs for most of my life.. I’m 75 now…I am one damn surviver! Raised 3 boys by myself and then my X husbands 3 teens. You have not idea what it is like trying too make very complicated decisions with kids and life..
    My brain was first hit with some kind of viral illness then I believe my illness turned into post viral syndrome only I never got my immune system back nor my brain.. Here I am 75 and I’ve been told by a nurse prac that I have by polar illness!! That was the biggest insult ever.. Slap me on some medicine then!! NOT.. I am not one to be a victim nor do I stand for it. The problem is no one can live in my brain or body so they can’t say much about it.. I can.. My journey is going to be written down before I lose my total memory.. I am happy that they finally found the brain problems. Also, I’ve had spect scans that show reduced blood flow to the frontal lobes and the bascil ganglion.. This a scarey stuff if you have it.. Panic attacks are from the illness or from living life that way.. Mine are both. I’ve had help with that and my doctor has me on an anti – viral for EBV and CMV..My herpes six A is under control right now. I am starting to have jerking at times and tremor.. My Mom had what I have and she went to her grave thinking she had Parkinson’s disease. I always knew she didn’t because the medicine they gave her immediately made her feet turn and and she became Paranoid fairly soon. She couldn’t walk from weakness and went into a wheel chair after one fall.. She didn’t want to fall again.. Anyway, the brain disorder may be able to get help for me. I have noticed that I’m not thinking as good ..I’ve had Altimer’s syptoms for years but it was transiant.. Went away when the illness got better.. I could tell you true stories that would make your hair curl up and fall out!!! Lol.. Anyway Thank God I am finally going to be verified and validated!!! Even my own doctor kinda treats me like I’m a hypo condriac.. Not even near that. At least he’s treating me for positive titers to EBV and CMV..IGG..Many tests over and over..
    I didn’t mean to go on and on but can you imagine having a really awful illness that hardly anyone believed me. My family and my own kids didn’t think CFIDS was a real illness.. Well, enough.. I am thankful to still be alive at 75 and able to see the beauty of the world.. I’ve coped so long that I live in fear for what the next day will bring for me. The brain is my master computer… My computer is not an ” Apple”… LOL.. Got to go now.. God Bless.. Nila Williams

    1. sara15 says:

      Hi Nila — Thanks for ‘going on’ about what you’ve been through. Sorry it’s been so almost-impossibly rough — but sharing even that bit of your experience is a huge inspiration. I’m soon to be 68 and have been ill for 20 years. First few were undiagnosed low thyroid (docs only cared about damned TSH, not what body was doing). I thought when that taken care of all would be well… but no. Won’t even go into range of symptoms mental & physical. But as you say, the disbelief of most of family and friends — and certainly of docs — made everything so much more difficult. I’m aiming to be able to be 75 and still fighting. Blessings on your brain and may serious researchers find something soon to help.

  2. nilagold says:

    Thank you for sharing and the much needed compliment.. I know I am a silent hero and so does God..
    Please write to me at I don’t care if I post my email..It will be worth connecting with others who have this illness..
    I am not giving up…never…You keep on thinking positive and realize that you are on a journey that will make you such a marvelous person..It matters…Your family and friends are only being frightened by something they don’t understand or they are judgemental people whom you don’t need.
    Sara, my dear child of God, know that I love you for what you are and I know that you will be ok.. Write me..In fact, anyone can write me on Face book as Nila Jean Shea.. God Bless..

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