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Stevia Extract Has Antimicrobial Effects Upon all Forms of Borrelia

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Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro

Abstract

Lyme disease is a tick-borne multisystemic disease caused by Borrelia burgdorferi. Administering antibiotics is the primary treatment for this disease; however, relapse often occurs when antibiotic treatment is discontinued. The reason for relapse remains unknown, but recent studies suggested the possibilities of the presence of antibiotic resistant Borrelia persister cells and biofilms.

In this study, we evaluated the effectiveness of whole leaf Stevia extract against B. burgdorferi spirochetes, persisters, and biofilm forms in vitro. The susceptibility of the different forms was evaluated by various quantitative techniques in addition to different microscopy methods. The effectiveness of Stevia was compared to doxycycline, cefoperazone, daptomycin, and their combinations.

Our results demonstrated that Stevia had significant effect in eliminating B. burgdorferi spirochetes and persisters. Subculture experiments with Stevia and antibiotics treated cells were established for 7 and 14 days yielding, no and 10% viable cells, respectively compared to the above-mentioned antibiotics and antibiotic combination. When Stevia and the three antibiotics were tested against attached biofilms, Stevia significantly reduced B. burgdorferi forms. Results from this study suggest that a natural product such as Stevia leaf extract could be considered as an effective agent against B. burgdorferi.

Source: By P. A. S. Theophilus, M. J. Victoria, K. M. Socarras, K. R. Filush, K. Gupta, D. F. Luecke, and E. Sapi*. Nov 12, 2015. Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro.Eur J Microbiol Immunol (Bp). (4): 268–280. Published online doi:  10.1556/1886.2015.00031

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One thought on “Stevia Extract Has Antimicrobial Effects Upon all Forms of Borrelia”

  1. linc87uk says:

    The Three Stages of Accomplishment on The Road to a Cure.
    There are 3 things to look at when you talk about accomplishments on the road to a cure. The First step is IN VITRO or in a petri dish . You hear very often about some scientist finding that something or other kill Borrellia in a petri dish. Recently it was Stevia and people were shouting from the rooftops. When you talk about herbs then all medicinal herbs are synergistic to some degree and a multitude of them will have in vitro activity. The main purpose of these kinds of studies is to get organization or college funding. In reality those studies don’t have much practical application at all but they impress the people who rally around those scientists. In the case of Stevia there are already numerous studies done on it’s medicinal activity, it won’t cure your “Lyme” disease though.
    http://www.rain-tree.com/stevia.htm#.VvPyc1UrKM8
    You can go to the bottom of the above link and see “Third-Party Published Research on Stevia”, it’s all been done before but it is a Nutramedix product and they are a benefactor of that University. So the first stage is somewhat meaningless.
    The second stage is IN VIVO or effectively killing all the bacteria causing the infections in your body. Things that affect this are bacterial resistance and tissue and bone tropism. In the case of synthetic antibiotics there are a lot of resistance factors. The bacteria are pleomorphic and change forms almost instantly when ABX are in the blood stream through Quorum Sensing, they also readily exchange DNA to share acquired resistance.
    https://www.sciencedaily.com/releases/2011/04/110411163918.htm
    http://www.ncbi.nlm.nih.gov/pubmed/23090599
    “we actually never had antibiotics capable of eradicating an infection. All pathogens produce a small subpopulation of dormant persister cells that are highly tolerant to killing by antibiotics. Once an antibiotic concentration drops, surviving persisters re-establish the population, causing a relapsing chronic infection. “
    A big factor in Tissue and Bone Tropism is the size of the molecules used in treatment . Molecules need to treat the brain and the threshold of the Blood Brain Barrier is 400 daltons , for bone penetration which are a collagen fibril matrix reinforced with minerals a molecule of 200 daltons or less is needed . The general rule of thumb used in pharmacology is 500 daltons but this is still too big.
    http://www.ncbi.nlm.nih.gov/pubmed/10839713
    Molecules like Azithromycin and Rifampin run around 800 daltons. So to accomplish the second step you need a treatment that has consistently small molecules and doesn’t offer any bacterial resistance. There is also a physical barrier to overcome and that is calcification which must be chemically broken down to treat what lies beneath these calcified plaques and crusts.
    http://www.pnas.org/content/95/14/7846.full.pdf
    “An infectious origin of extraskeletal calcification”
    Taking these factors in to account when seeking a remedy is important to achieve the second step. Bartonella is the calcifying bacteria in question, Brucella also does this. The calcified plaques contain all the microbes including Borrelia and Babesia, etc. so they must be broken down.
    The Third step of accomplishment on a road to a cure is realizing that Bartonella is a transgenic bacteria and creates tumors and mutated cells. Mutated cells have received DNA transfer from Bartonella and will continue to grow even if you kill the Bartonella. Bartonella aters DNA and shuts down the immune system.
    http://www.pnas.org/content/108/35/14643.abstract
    “Conjugative DNA transfer into human cells by the VirB/VirD4 type IV secretion system of the bacterial pathogen Bartonella henselae”
    http://www.ncbi.nlm.nih.gov/pubmed/9247895
    “Bartonellosis and human immunodeficiency disease (AIDS): L-forms as persisters, activating factors, and mechanism of disease.”
    So when treating a Bartonella infection the reality is that you also have to treat something akin to Cancer in order to be successful. Some people are just starting to realize this. The NB protocol accomplishes ALL THREE.
    http://www.huffingtonpost.com/dana-parish/lyme-the-infectious-disea_b_9243460.html
    “Lyme: The Infectious Disease Equivalent of Cancer, Says Top Duke Oncologist”
    The NB protocol
    http://www.lyme-morgellons.com

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