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Strong IgG antibody responses to Borrelia burgdorferi glycolipids in patients with Lyme arthritis, a late manifestation of the infection.

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In this study, the membrane lipids of B. burgdorferi were separated into 16 fractions; the components in each fraction were identified, and the immunogenicity of each fraction was determined by ELISA using sera from
Lyme disease patients. Only the 2 glycolipids, acylated cholesteryl galactoside (ACG, BbGL-I) and monogalactosyl diacylglycerol (MgalD, BbGL-II), were immunogenic. Early in the infection, 24 of 84 patients (29%) who were convalescent from erythema migrans and 19 of the 35 patients (54%) with neuroborreliosis had weak IgG responses to purified MgalD, and a smaller percentage of patients had early responses to synthetic ACG. However, almost all of 75 patients with
Lyme arthritis, a late
disease manifestation, had strong IgG reactivity with both glycolipids. Thus, almost all patients with
Lyme arthritis have strong IgG antibody responses to B. burgdorferi glycolipid antigens.

Clin Immunol. 2009 Jul;132(1):93-102. doi: 10.1016/j.clim.2009.03.510. Epub 2009 Apr 2. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov’t

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