Collagen deposits around the nerve fibers may contribute to lower pain thresholds at tender point locations in fibromyalgia (FM) patients, according to a recent study.
Collagen is a fibrous protein found in tendons, ligaments, and cartilage and is the building block for all connective tissue.
The study, conducted by the Department of Rheumatology and the Institute of Physical Therapy/University Hospital of Zurich, analyzed collagen metabolites in the urine and serum of 39 FM patients and 55 non-FM patients.) Two key indicators of connective tissue and bone degradation, Pyridinoline (Pyd) and deoxypyridinoline (Dpydwere analyzed by ion-paired and gradient HPLC method using fluorescence detection. Hydroxypyroline (Hyp) levels, a collagen turnover marker, were also measured.
Results of the study showed that the Pyd/Dpyd ratios in the urine and serum and the Hyp in the urine were significantly lower in the FM patients. These decreased levels may contribute to the remodeling of collagen and lead to deposits around the nerve fibers.