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Sulfur & MSM: Often Overlooked Foundation of Energy, Muscle & Joint Health

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The mineral sulfur, a vital building block of healthy, elastic connective tissue, joints & skin, is also crucial for mitochondrial energy generation. And MSM is an ideal source of organic sulfur, which the cells can more readily use, says natural health expert Joseph Mercola, MD.

This explanation of sulfur’s many roles in health is excerpted with kind permission from Dr. Mercola’s educational website (Mercola.com). It was first published Sep 12, 2011. See footnote for much more.*


Sulfur: The Mineral that Helps the Body Fight Fatigue, Stress, Pain… and Wrinkles, Too

Sulfur is the third most abundant mineral in your body, after calcium and phosphorous. It’s an important mineral element that you get almost wholly through dietary proteins, yet it’s been over 20 years since the U.S. Food and Nutrition Board (FNB) issued its last update on recommended daily allowances (RDA) for it.

In a study examining critical elements about how sulfur works in the body, researchers say the importance of this mineral may be underestimated, and that it’s possible we may not be getting enough of it.

[See “Are we getting enough sulfur in our diet?” by a team at USC’s Keck School of Medicine, highlighting how little research has been done on optimum sulfur intake, and reporting that while younger people eating plenty of protein average about 6.8 grams of sulfur amino acids per day, older people as a group average just 1.8 grams.]

The Importance of Sulfur

Close to half of the sulfur in your body can be found in your muscles, skin and bones, but it does much more than benefit just these three areas. It plays important roles in many bodily systems.

Sulfur bonds are required for proteins to maintain their shape, and these bonds determine the biological activity of the proteins. For example… hair and nails consist of a tough protein called keratin, which is high in sulfur, whereas connective tissue and cartilage contain proteins with flexible sulfur bonds, giving the structure its flexibility.

With age, the flexible tissues in your body tend to lose their elasticity, leading to sagging and wrinkling of skin, stiff muscles and painful joints. A shortage of sulfur likely contributes to these age-related problems.

In addition to bonding proteins, sulfur is also required for the proper structure and biological activity of enzymes.

If you don’t have sufficient amounts of sulfur in your body the enzymes cannot function properly, which can cascade into a number of health problems as without biologically active enzymes, your metabolic processes cannot function properly.

Sulfur also plays an important role in:

• Your body’s electron transport system, as part of iron/sulfur proteins in mitochondria, the energy factories of your cells

• Vitamin-B thiamine (B1) and biotin conversion, which in turn are essential for converting carbohydrates into energy

• Synthesizing important metabolic intermediates, such as glutathione  

• Proper insulin function. The insulin molecule consists of two amino acid chains connected to each other by sulfur bridges, without which the insulin cannot perform its biological activity

• Detoxification.

The [USC study] looked at a broad scope of overlapping metabolic pathways in order to determine which ones may be affected by insufficient intake of dietary sulfur. They also evaluated the modes of action of a variety of sulfur-containing dietary supplements, including chondroitin and glucosamine, commonly used to improve joint health.

According to the authors:

“Sulfur amino acids contribute substantially to the maintenance and integrity of the cellular systems by influencing cellular redox state and the capacity to detoxify toxic compounds, free radicals and reactive oxygen species.

“… Sulfur containing metabolites, of which glutathione is a key exponent, merge in their functioning with many other compounds that play a major role in mechanisms which are receiving tremendous interests as parts of conventional and complementary medical care. These include the omega-3 and omega-6 polyunsaturated fatty acids, minerals such as Selenium, Zinc, Copper and Magnesium, vitamins E and C, antioxidants such as the proanthocyanidins, and lipoic acid, many of which are involved in the synthesis of prostaglandins and in the antioxidant cascade.

“More and more evidence is accumulating and focusing on the cooperative role that glutathione and other sulfur metabolites play in the homeostatic control of these fundamental mechanisms.”

Are You Getting Enough Sulfur in Your Diet?

As stated in the [USC article], only two of the 20 amino acids normally present in foods contain sulfur:

1. Methionine, which cannot be synthesized by your body and must be supplied through diet, and

2. Cysteine, which is synthesized by your body but requires a steady supply of dietary sulfur in order to do so.

Neither of these is stored in your body. Rather, “any dietary excess is readily oxidized to sulphate, excreted in the urine (or reabsorbed depending on dietary levels) or stored in the form of glutathione (GSH),” according to the researchers.

Glutathione is composed of three amino acids: cysteine, glutamate, and glycine, and is your body’s most potent antioxidant, which also keeps all other antioxidants performing at peak levels. [See “This ONE Antioxidant Keeps All Other Antioxidants Performing at Peak Levels.”]

Furthermore the USC team states:

“The availability of cysteine appears to be the rate limiting factor for synthesis of glutathione (GSH). GSH values are subnormal in a large number of wasting diseases, and following certain medications leading frequently to poor survival. By supplying sulfur amino acids (SAA) many of these changes can be reversed.

“In the brain, which is usually the most spared organ during nutrient deficiencies, GSH concentration declines in order to maintain adequate levels of cysteine. This loss of GSH impairs antioxidant defences…

“Cartilage, less essential for survival, may not fare well under conditions of sulfur deprivation, explaining why dietary supplements containing sulfur (chondroitin sulfate, glucosamine sulfate, MSM (Methylsulfonylmethane), etc.) may be of benefit in the treatment of joint diseases.”

In conclusion, they state that:

“Out of this study came information that suggested that a significant proportion of the population that included disproportionally the aged, may not be receiving sufficient sulfur and that these dietary supplements, were very likely exhibiting their pharmacological actions by supplying inorganic sulfur.”

Dietary Sources of Sulfur

The best and most ideal way to obtain sulfur is through your diet. Sulfur is derived almost exclusively from dietary protein, such as fish and high-quality (organic and/or grass-fed/pastured) beef and poultry.

Meat and fish are considered “complete” as they contain all the sulfur-containing amino acids you need to produce new protein. Needless to say, those who abstain from animal protein are placing themselves at far greater risk of sulfur deficiency.

Other dietary sources that contain small amounts of sulfur include organic pastured eggs, legumes (peas, lentils & beans), garlic, onion, Brussels sprouts, asparagus, kale, and wheat germ.

MSM, an Organic Form of Sulfur

Methylsulfonylmethane, commonly known by its acronym, MSM, is not a drug. It’s an organic form of sulfur and a potent antioxidant, naturally found in many plants. [By comparison with inorganic minerals, organic minerals have been made by plants or other living organisms which draw inorganic minerals from the soil and convert them to a form that can be readily utilized by living cells.]

While MSM is an important source of organic sulfur, it also has other unique properties. Common health complaints associated with low concentrations of MSM in your body include:

• Fatigue

• Depression

• High sensitivity to physical and psychological stress

• Degenerative diseases.

MSM’s ability to help neutralize inflammation is one of the greatest, and one of the most inexpensive, discoveries in the health field, and is thought to be particularly beneficial in the prevention of heart disease.

It has been shown to support breakdown of the plaque in your arteries, which is associated with chronic inflammation.

Other health benefits associated with MSM [as detailed in “The MSM Miracle” and based on its role as a component of healthy cells, tissues, and organs] include:

• Reducing chronic pain

• Promoting cellular uptake of many nutrients including vitamins A, B, C, D, E, amino acids, selenium, calcium, magnesium, coenzyme Q10….

• Reducing or eliminating muscle soreness and cramps

• Detoxification [the article suggests MSM “drastically increases the ability of cells to excrete toxic waste products”]

• Alleviating symptoms of allergies

• Supporting anti-parasitic action against Giardia, Trichomonas, roundworms, nematodes, Enterobius and other intestinal worms

• Improving lung function by allowing your body to more effectively take up oxygen

• Preventing neurological disease by supporting repair of oxidative damage and restoration of cell membrane elasticity and permeability

• Preventing and reducing symptoms of autoimmune diseases by supporting reduction of chronic inflammation

• Helping to prevent diabetes by promoting healthy insulin function

• Supporting increased strength and endurance, and reduced stress.

Sources of MSM, and Dosages

MSM can be found in raw grass-fed milk, fresh vegetables, and  fruits. The amounts of sulfur you can obtain from these sources range between one to five mg/kg [note one kilogram = 2.2 pounds]. Raw pastured milk contains the highest amounts of MSM: between two to five mg/kg.

However, it’s important to know that MSM is rapidly lost during heating.

So pasteurized milk is not a good source. It contains less than 0.25 mg/kg MSM. Ditto for thoroughly cooked vegetables, and fruits and vegetables kept for a period of time.

Hence, you’ll want to consume most of your veggies raw as soon as possible after harvesting. If you eat a diet consisting primarily of processed and thoroughly cooked foods, you can be virtually guaranteed that you’re not getting sufficient amounts of sulfur in your diet.

MSM is also highly concentrated in aloe vera, so you can use natural aloe vera products to increase your intake of MSM in its natural form.

Another alternative is to take MSM as a dietary supplement.

In a previous interview, superfood expert David Wolfe recommended taking about 2,500 mg per day to start; slowly working your way up to about 5,000 to 7,500 mg per day.

Keep in mind that there may be side effects because MSM can detoxify you, and that may initially aggravate any condition you have. So increase dosage slowly to allow your body to adjust. Avoid increasing the dose until all detox symptoms have disappeared. Also, avoid taking MSM at night, as it may increase your energy levels.

As with most supplements, quality is a concern when it comes to MSM as well.  It’s important to note that if you’re allergic to sulfa drugs, you may also have trouble with MSM.

Aside from that, MSM is extremely non-toxic. So far no one has found an upper limit at which point it causes toxic effects. This fact makes it an ideal form of sulfur supplementation, as the sulfur-containing amino acids methionine and cysteine can both cause toxic symptoms at large doses.

–  Joseph Mercola, MD

* Source: 

Dr. Mercola is the founder of the world’s most visited natural health web site, Mercola.com. You can learn the hazardous side effects of OTC Remedies by getting a FREE copy of his latest special report The Dangers of Over the Counter Remedies by going to his Report Page.

Note: This information (© 1997-2011 Dr. Joseph Mercola. All Rights Reserved) has not been reviewed by the FDA. It is general information, based on the research and opinions of Dr. Mercola unless otherwise noted, and is not meant to prevent, diagnose, treat or cure any condition, illness, or disease. It is not intended to replace a one-on-one relationship with a qualified healthcare professional and is not intended as medical advice. It is always very important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.

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One thought on “Sulfur & MSM: Often Overlooked Foundation of Energy, Muscle & Joint Health”

  1. rute47 says:

    Dr. Mercola included a warning about a possible allergic reaction to products with sulfur
    if one has an allergic reaction to sulfa drugs. I have side effects from sulfa drugs but
    never had any problem with sulfur products like MSM. The difference between organic
    sulfur and sulfa drugs looks to be such that there little cause for worry, at least as far
    as I am concerned. The article in the link below included a good explanation about this.


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