Xenotropic murine leukemia virus-related virus (XMRV) is a recently discovered gammaretrovirus that has been linked to prostate cancer and chronic fatigue syndrome. This virus is therefore an important potential human pathogen and, as such, it is essential to understand its host cell tropism [how it has evolved to target specific cells in a host species].
Intriguingly, infectious virus has been recovered from patient-derived peripheral blood mononuclear cells.
These cells express several antiviral restriction factors that are capable of inhibiting the replication of a wide range of retroviruses, including other gamma retroviruses.
This raises the possibility that, similar to HIV, XMRV may have acquired resistance to restriction.
We therefore investigated the susceptibility of XMRV to a panel of different restriction factors. We found that:
• Both human APOBEC3 and tetherin proteins are able to block XMRV replication.
• Expression of human TRIM5?, however, had no effect on viral infectivity.
There was no evidence that XMRV expressed countermeasures to overcome restriction.
In addition, the virus was inhibited by factors from nonhuman species, including mouse Apobec3, tetherin, and Fv1 proteins.
These results have important implications:
• For predicting the natural target cells for XMRV replication,
• For relating infection to viral pathogenicity and pathology,
• And for the design of model systems with which to study XMRV-related diseases.
Source: Proceedings of the National Academy of Sciences (PNAS), Mar 1, 2010. Groom HCT, Yap MW, Galao RP, Neil SJD, Bishop KN. Columbia University College of Physicians and Surgeons, New York, NY, USA. [firstname.lastname@example.org]