[Note: Temporomandibular disorder involves tenderness and pain in the joint of the jaw. A polymorphism is a genetic variation occurring in more than 1% of the population, by contrast with a mutation.]
Journal: Biopsychosocial Medicine. 2007 Jan 10;1:3. [Full text of study findings, table, and references are available online at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1805776]
Authors and affiliation: Ojima K, Watanabe N, Narita N, Narita M. Graduate School Human Sciences, University of Tsukuba, Ibaraki, Japan. [E-mail: firstname.lastname@example.org ]
Aims: Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including Chronic Fatigue Syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder.
Methods: We investigated three serotonin-related genetic polymorphisms by screening genomic DNA of 36 temporomandibular disorder (TMD) patients.
Results: A significant increase of longer alleles (l and xl) was found in the TMD patients compared to the controls both by the genotype-wise and the allele-wise analyses (both p < 0.01 by chi2 test and Fisher's exact test).
Conclusion: Genetic factors that involve the serotonergic system may play a role in the pathogenesis of TMD.