Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population

[Note: Temporomandibular disorder involves tenderness and pain in the joint of the jaw. A polymorphism is a genetic variation occurring in more than 1% of the population, by contrast with a mutation.]

Journal: Biopsychosocial Medicine. 2007 Jan 10;1:3. [Full text of study findings, table, and references are available online at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1805776]

Authors and affiliation: Ojima K, Watanabe N, Narita N, Narita M. Graduate School Human Sciences, University of Tsukuba, Ibaraki, Japan. [E-mail: narita_m@doc.medic.mie-u.ac.jp ]

PMID: 17371573

Aims: Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including Chronic Fatigue Syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder.

Methods: We investigated three serotonin-related genetic polymorphisms by screening genomic DNA of 36 temporomandibular disorder (TMD) patients.

Results: A significant increase of longer alleles (l and xl) was found in the TMD patients compared to the controls both by the genotype-wise and the allele-wise analyses (both p < 0.01 by chi2 test and Fisher's exact test).

Conclusion: Genetic factors that involve the serotonergic system may play a role in the pathogenesis of TMD.

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