10% Off $75 Orders! Use Code SAVE10P Shop Now
One use per customer. Not available with Autoship. Expires 5/28/18.

The Chronic Fatigue Syndrome – An update

1 Star2 Stars3 Stars4 Stars5 Stars (461 votes, average: 2.95 out of 5)
Loading...

Journal: Acta Neurologica Scandanavica Supplementum. 2007;187:7-14.

Author and affiliation: Wyller VB. Department of Pediatrics, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway.

PMID: 17419822

Background – In this article, current scientific knowledge on the Chronic Fatigue Syndrome (CFS) is reviewed. The U.S. case definition of CFS (the CDC definition) is most widespread in research and clinical practice. Estimates of prevalence vary from 0.2% to above 2%. The female-male ratio is approximately 3:1.

Clinical Features – Severe fatigue is the dominating complaint; it is worsened from exertions and not substantially relieved by rest. In addition, the patients might have a varying combination of accompanying symptoms. Clinical evaluation should be based upon standardized guidelines, including an assessment of functional impairments.

Pathophysiology – The pathophysiology should be interpreted within a biopsychosocial framework. Present knowledge suggests that certain genetic polymorphisms and personality traits might be regarded as predisposing factors, some infections and severe psychosocial stress constitute precipitating factors, whereas disturbances of immunity, skeletal muscle, cognitive abilities, endocrine control and cardiovascular homeostasis are possible perpetuating factors.

Treatment – Cognitive behavioural therapy and graded exercise therapy are of proven value in randomized controlled trials. Several pharmaceutical measures have been explored and found to have no beneficial effect. Most patients might expect long-term improvement, but full recovery is rare; however, the prognosis is better among adolescents.

1 Star2 Stars3 Stars4 Stars5 Stars (461 votes, average: 2.95 out of 5)
Loading...



One thought on “The Chronic Fatigue Syndrome – An update”

  1. JustAnEngr06 says:

    More psychobabble!

Leave a Reply