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Only a few investigations have been conducted into the incidence of
Lyme borreliosis and the prevalence and clinical value of increased antibody titers against Borrelia burgdorferi. We prospectively examined 241 persons and found increased titers in 23 (9.5%); only two of them had a history of
Lyme borreliosis. The concentrations of increased IgG-antibody titers in healthy persons were comparable to those in patients with actual
Lyme borreliosis. In the latter, IgM-antibodies were frequently absent. Our results suggest an infection rate of about 10% in this region of Switzerland. They further emphasize that the diagnosis of
Lyme borreliosis must primarily be established clinically and by exclusion of other etiology.