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Lyme borreliosis (LB) is a multisystem
disease caused by infection with Borrelia burgdorferi sensu lato (B.b). LB is the most common human tick-borne
disease, transmitted principally by species of Ixodes ricinus in Europe, I. persulcatus in Eurasia, I. scapularis and I. pacificus in North America. B.b has been isolated or detected in 24 different species of mammals or birds. The B31 strain of B.burgdorferi sensu stricto is predominant in United States and in Europe B. garinii, B. afzelii and B. burgdorferi sensu stricto.