The importance of orthostatic intolerance in the Chronic Fatigue Syndrome (CFS)

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Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis is

a clinically defined syndrome characterized by persistent or

relapsing debilitating fatigue for longer than 6 months in the

absence of any definable medical diagnosis. The cause of this

syndrome is unknown. Symptoms of orthostatic intolerance, such

as disabling fatigue, dizziness, diminished concentration,

tremulousness, and nausea, are often found in patients with

CFS. In this review, we critically evaluate the relationship

between orthostatic intolerance and CFS. Particular emphasis

is placed on clinical diagnosis, laboratory testing,

pathophysiology, and therapeutic management. It is hoped that

this review will provide a stimulus for further study of this

complex and disabling condition.

Schondorf R, Freeman R

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