The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with Chronic Fatigue Syndrome (CFS)

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In humans, eight monosaccharides are required for the synthesis of

glycoproteins. Dietary supplements that supply these crucial

sugars are known as glyconutrients. A glyconutrient compound

was added to Peripheral Blood Mononuclear Cells (PBMC)

isolated from normal controls and patients with the Chronic

Fatigue Syndrome (CFS), a disease associated with immune

dysregulation. The in vitro immunomodulatory effects were

investigated. Cell surface expression of the glycoproteins

CD5, CD8, and CD11a were significantly lower in patients with

CFS compared to normal controls. Addition of glyconutrient

homogenate to PBMC from patients with CFS stimulated with

phytohemagglutinin significantly increased the expression of

each glycoprotein. Furthermore, natural killer (NK) cell

function was reduced in CFS patients. The glyconutrient

preparation significantly enhanced NK cell activity versus

human herpes virus 6 (HHV-6)-infected H9 cells in an 8 h 51Cr

release assay compared to placebo for PBMC from patients with

CFS (p< .01). Finally, apoptosis was significantly higher in

patients with CFS. The percentage of apoptotic cells was

significantly decreased in PBMC from patients with CFS that

had been incubated for 48 h with glyconutrients. Thus,

glyconutrients improved abnormal immune parameters in vitro in

patients with CFS.

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