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The pathogenesis of chronic pain & fatigue syndromes, with special reference to fibromyalgia (FM)

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Syndromes characterized by chronic pain and fatigue have been
described in the medical literature for centuries.
Fibromyalgia is the term currently used to describe this
symptom complex, and considerable research has been performed
in the last decade to delineate the epidemiology,
pathophysiology, and genesis of this entity. Although
fibromyalgia is defined by its musculoskeletal features, it is
clear that there are a large number of non-musculoskeletal
symptoms, such that we now understand that there is
considerable overlap with allied conditions such as the
chronic fatigue syndrome, migraine and tension headaches,
irritable bowel syndrome, and affective disorders. This
article will review our current state of knowledge regarding
fibromyalgia and these allied conditions, and present a
unifying hypothesis that describes both the pathophysiology of
symptoms and the genesis of these disorders. [References: 83]

Clauw DJ

1 Star2 Stars3 Stars4 Stars5 Stars (13 votes, average: 2.70 out of 5)
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