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The relationship between fibromyalgia (FM) & major depressive disorder

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Looking at the results of the seven types of studies discussed

previously, it appears that there is strong evidence for an

association between fibromyalgia and major depressive

disorder on the basis of (1) overlapping symptomatology, (2)

similar pattern of comorbid disorders, and (3) high rates of

major depressive disorder among relatives of patients with

fibromyalgia. There is additional support for an association

on the basis of responses to psychological tests and rating

scales and the high lifetime rates of mood disorders in

fibromyalgia. Two lines of evidence, (1) response to

antidepressant medications and (2) response to biologic

tests, offer little evidence either for or against an

association. On balance, then the weight of the evidence

favors an association between fibromyalgia and major

depressive disorder. We therefore turn to an analysis of the

nature of the association.

Hudson JI, Pope HG Jr

1 Star2 Stars3 Stars4 Stars5 Stars (52 votes, average: 2.85 out of 5)
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