The responsiveness of generic quality of life instruments in rheumatic diseases. A systematic review of randomized controlled trials – fibromyalgia related research

To review the available evidence that has used generic

instruments alone or in comparison with disease specific

instruments. A systematic review was carried out using the

methods recommended by the Cochrane Collaboration. We used

MEDLINE and EMBASE searches and we performed a hand search of

the abstracts listed under “quality of life” at American

College of Rheumatology (ACR) meetings. Selection was limited

to randomized controlled trials (RCT) using generic

instruments in populations older than 18 years with any of the

following diseases: rheumatoid arthritis, fibromyalgia,

osteoporosis, osteoarthritis, systemic lupus erythematosus,

and ankylosing spondylitis.

Language was restricted to English

papers. Studies using only disease-specific instruments were

excluded. From 488 articles retrieved, 13 reports of 10

randomized controlled trials were selected. There were 101

abstracts on quality of life in ACR abstract books; 78

abstracts contained data on generic instruments, and of these,

9 described their use in RCT. Despite a substantial increase

in the number of papers and abstracts addressing different

aspects of generic questionnaires, the majority of the papers

were descriptive.

The evidence is not yet available to

document that any of the generic instruments pass the

requirements of the OMERACT Filter.

Ortiz Z, Shea B, Garcia Dieguez M, Boers M, Tugwell P, Boonen A,

Wells G

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