OBJECTIVE: To replicate the treatment study by Behan et al.
(1990) using current research criteria for Chronic Fatigue
METHOD: Fifty patients who fulfilled the
Oxford Criteria for CFS were randomly allocated to treatment
with either Efamol Marine or placebo for 3 months. They were
seen monthly and completed a physical symptoms checklist and
the Beck Inventory for Depression and reported if they were
the same, better or worse at the end of the study.
Symptoms generally improved with time but not significantly
and there were no significant differences between the
treatment and placebo groups. Pretreatment red-cell membrane
(RBC) lipids of patients compared with age-and sex-matched
normal controls showed no significant differences.
The results of this study contrast sharply with the previous
study where 85% of patients had a clinically significant
improvement of symptoms with Efamol Marine over a 3-month
Warren G, McKendrick M, Peet M