The treatment of Chronic Fatigue Syndrome (CFS): science & speculation

The chronic fatigue syndrome (CFS) is a heterogeneous disorder

characterized by fatigue, neuropsychiatric symptoms, and

various other somatic complaints. Treatment studies to date

reflect both the diversity of medical disciplines involved in

the management of patients with CFS and the multiple

pathophysiologic mechanisms proposed. There have been few

attempts to study integrated treatment programs, and although

several controlled studies have been reported, no treatment

has been shown clearly to result in long-term benefit in the

majority of patients. Good clinical care integrating medical

and psychologic concepts, together with symptomatic

management, may prevent significant secondary impairment in

the majority of patients. Future treatment studies should

examine differential response rates for possible subtypes of

the disorder (eg, documented viral onset, concurrent clinical

depression), evaluate the extent of any synergistic effects

between therapies (ie, medical and psychologic), and employ a

wide range of biologic and psychologic parameters as markers

of treatment response. [References: 77]

MCM: A good broad and broad-minded view of CFS Rx, with

emphasis on multidisciplinary approach.

Wilson A, Hickie I, Lloyd A, Wakefield D

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