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Lyme Disease has been called “The New Great Imitator,” a replacement for that old “great imitator” neurosyphilis. This article reviews the numerous psychiatric and neurologic presentations found in adults and children. It then reviews the features of
Lyme Disease, which makes it almost uniquely hard to diagnose, including the complexity and unreliability of serologic tests. Clinical examples follow that illustrate those presentations of this
disease that mimic attention deficit hyperactivity disorder (ADHD), depression, and multiple sclerosis.