The Journal of Alzheimer’s Disease reported positive results for a combination of three nutrients in the prevention of Alzheimer’s disease in older individuals.*
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The trial included 918 participants in the Tone Project, which enrolled men and women aged 65 years and older. Subjects were offered the choice of receiving nutritional supplementation, taking part in a two-year exercise program, or participating in both. Beginning in 2002, 171 men and women who elected to receive supplements were given capsules containing 290 mg EPA and 203 mg DHA from fish oil, 240 mg Ginkgo biloba extract, and 84 mg lycopene for three years. Neuropsychological testing was administered at the beginning of the study and at the first and second follow-up visits during 2004-2005 and 2008-2009.
Over follow-up, 76 subjects were diagnosed with Alzheimer’s disease. Adherence to the supplement regimen was associated with a 31% lower adjusted risk of the disease in comparison to no supplementation.
LEF Editor’s Note: Those engaging in the exercise regimen were associated with a 21% lower risk of Alzheimer’s disease compared with those who did not take part in the program. The benefit, however, was no longer observed after adjustment for a number of factors.
Reference: J Alz Dis . 2014 Dec 16.