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Recent research conducted at the University of Western Australia has shown that glucosamine supplementation may provide some degree of pain relief and improved function in people who experience chronic knee pain. In this randomized, placebo controlled study, 46 subjects were selected to receive 2,000mg per day of glucosamine or placebo for twelve weeks. During this period, four separate clinical testing sessions were performed to assess changes in knee pain and function. The study results showed clinical and functional test scores improved over time, and self reported evaluations showed 88% of subjects in the glucosamine group reported some degree of improvement in knee pain, versus only 17% in the placebo group. The researchers concluded the report stating that 2,000mg of glucosamine per day can provide some degree of pain relief.

(Source: British Journal of Sports Medicine 2003 Feb;37(1):45-9)

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