Several European studies have documented Pycnogenol® ability to alleviate the symptoms of CVI (chronic venous insufficiency), including the swelling in the legs that leads to varicose veins. In a study published last year in Phytotherapy Research, 40 patients with CVI were treated daily with either 360 mg of Pycnogenol® or 600 mg of horse chestnut seed extract (Aesculus hippocastanum), another herbal remedy commonly used to treat CVI. After four weeks, those taking Pycnogenol® experienced a 50 percent decrease in leg pain and cramping and a 33 percent decrease in nighttime leg swelling. Patients taking horse chestnut seed extract did not experience significant changes.
Similar results were found in a double-blind study published in an Italian journal in 2000. In the study, 40 patients with CVI took either 100 mg of Pycnogenol® three times daily or a placebo. After 60 days, the Pycnogenol® group reported 64 percent less leg swelling and leg pain. The placebo group experienced no significant reductions.
(Source: Natural Health magazine, online at www.naturalhealthmag.com.)