The liver is one of the primary targets of Epstein-Barr Virus (EBV), Cytomegalovirus (CMV), and some other viruses associated with Chronic Fatigue Syndrome. Indeed, most people suffering from acute EBV disease (mononucleosis) or chronic EBV (CEBV) develop subacute hepatitis. The liver is also one of the major powerhouses of the body and, when it is badly infected, disruption of both the metabolism and the immune system results, followed by fatigue – a main hallmark of CEBV disease, and depression. Thus, it is essential that the liver be treated.
(Source: Chronic Fatigue Syndrome: The Hidden Epidemic, by Jesse E. Stoff, M.D., and Charles R. Pellegrino, Ph.D.)