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Systemic diseases and other musculoskeletal or nonmusculoskeletal conditions may develop during the course of FMS. Any symptom not compatible with a diagnosis of FMS or a change in the nature of symptoms should be evaluated carefully because it may be a clue indicating coexistent process. Failure to recognize and manage concomitant conditions may augment patients' symptoms and result in unsuccessful management of FMS. (Source: "Fibromyalgia: 20 Clinical Pearls", by Lawrence J. Levanthal, M.D., and Henda Bouali, M.D. Published in the Journal of Musculoskeletal Medicine, Volume 20, Number 2, February 2003.)

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