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A few well-designed clinical trials have looked at the effects of magnesium supplementation on fibromyalgia. Some studies have shown that people with fibromyalgia have low levels of magnesium or of ATP. A 1995 placebo-controlled study examined the effect of magnesium and malic acid on people with fibromyalgia and found that high doses relieved pain and boosted energy [Jour Rheumatology 1995;22(5):953]. Another placebo-controlled study found similar results combining magnesium with malate; participants taking the supplement saw improvement within 48 hours [Jour Nutr Med 1992;3:49] (Source: Natural Treatments for Fibromyalgia: An A to Z Guide, by Kenna Simmons. An official publication of the Arthritis Foundation. To purchase, visit www.arthritis.org.)

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