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In addition to being investigated for neuroprotective properties in degenerative disease, creatine has been studied for its potential to prevent mental fatigue. Because creatine is known for reducing muscle fatigue and improving physical performance, researchers at the University of Tokyo decided to test whether creatine could affect mental performance. At a dose of 8 grams/day for five days, creatine reduced mental fatigue and increased brain oxygen utilization in subjects performing simple mathematical calculations.

(Source: Natural Products Industry Insider, 2/2/04. Online at www.naturalproductsinsider.com.)

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