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When the complex functioning of the immune system is disrupted, its components and functions can be upregulated (overreactive) or downregulated (underreactive). When upregulated, the components of the immune system are switched on and left on, and the host becomes reactive to all types of substances perceived as "nonself." Symptoms associated with battle and illness are produced. The ratio of helper to suppressor T-cells functions as the on-off switch of the immune system, with a normal ratio of 2:1 or 3:1. The balance between them is critical to proper immune response and functioning. During and following illness, this ratio varies. (Source: Chronic Fatigue Syndrome, Fibromyalgia, and Other Invisible Illnesses – The Comprehensive Guide, by Katrina Berne, Ph.D. Published by Hunter House books and available at www.hunterhouse.com.)

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