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TNF-alpha & Chronic Fatigue Syndrome (CFS)

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Based upon the clinical presentation of chronic fatigue

syndrome (CFS), we hypothesized that proinflammatory cytokines

may play a role in the pathogenesis of the disease. We

therefore undertook a retrospective cross-sectional study to

examine the role of TNF-alpha in patients with CFS. Our

results suggest a significant increase serum TNF-alpha in

patients with CFS (P<0.0001) compared to non-CFS controls.

This study supports the further examination of the role of

proinflammatory mediators in CFS. Furthermore, the clinical

testing of TNF-alpha blockers and other antiinflammatory

agents for the treatment of this disease is warranted.

Moss RB, Mercandetti A, Vojdani A

1 Star2 Stars3 Stars4 Stars5 Stars (22 votes, average: 2.75 out of 5)
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