Based upon the clinical presentation of chronic fatigue
syndrome (CFS), we hypothesized that proinflammatory cytokines
may play a role in the pathogenesis of the disease. We
therefore undertook a retrospective cross-sectional study to
examine the role of TNF-alpha in patients with CFS. Our
results suggest a significant increase serum TNF-alpha in
patients with CFS (P<0.0001) compared to non-CFS controls.
This study supports the further examination of the role of
proinflammatory mediators in CFS. Furthermore, the clinical
testing of TNF-alpha blockers and other antiinflammatory
agents for the treatment of this disease is warranted.
Moss RB, Mercandetti A, Vojdani A