Treatment of Chronic Fatigue [Syndrome] and orthostatic intolerance with propranolol

[Note: propranolol is a ‘beta blocker’ mainly used in treatment of high blood pressure. It blocks epinephrine (adrenalin), the sympathetic nervous system’s “fight or flight” stress-reaction hormone. Orthostatic intolerance is an inappropriate heart rate and blood pressure response to a change in body position from prone to upright.]

Journal: Journal of Pediatrics. 2007 Jun;150(6):654-5.

Authors and affiliation: Wyller VB, Thaulow E, Amlie JP. Department of Pediatrics, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway. [E-mail: ]

PMID: 17517256

We describe the effect of propranolol in an adolescent with Chronic Fatigue Syndrome and orthostatic intolerance.

Our observations suggest that the head-up tilt-test and beta-blocker treatment might be considered in patients with Chronic Fatigue Syndrome and that enhanced sympathetic nervous activity might be part of the underlying pathophysiology.

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