Treatment-Resistant Woman with Fibromyalgia Experiences Marked Improvement with Dextroamphetamine

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Editor’s comment: Dextroamphetamine is a central nervous system stimulate. “Uppers” is a colloquial term often used to describe this class of drugs. It is labeled as having high abuse potential and dependency. Dextroamphetamine has been FDA approved for the treatment of ADHD, narcolepsy and obesity. Although this patient experienced significant improvement, it’s important to keep in mind that this is a case study of just one patient so we can’t draw conclusions for other FM patients without more extensive studies.

Marked improvement of pain from long-term fibromyalgia with dextroamphetamine sulfate in a woman who failed to improve with conventional pharmacologic treatment.

By J.H. Check and R. Cohen


PURPOSE: To determine if treatment with the sympathomimetic amine dextroamphetamine sulfate, which has been so effective in treating a variety of pain syndromes, including severe pelvic pain and interstitial cystitis in women with the sympathetic neural hyperalgesia edema syndrome would also mitigate pain from fibromyalgia which was resistant to multiple therapies.

MATERIALS AND METHODS: Dextroamphetamine sulfate extended release capsules once daily was gradually increased to 25 mg per day in a woman with treatment resistant fibromyalgia of 20 years duration.

RESULTS: Within a short time, the woman experienced dramatic relief of pain. Furthermore, her edema improved resulting in a 27 pound weight loss and her chronic fatigue improved.

CONCLUSIONS: Fibromyalgia can be effectively treated with an innocuous dose of dextroamphetamine sulfate.

Source: Clinical and Experimental Obstetrics and Gynecology, 2014. By J.H. Check and R. Cohen.