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Urinary free cortisol excretion in Chronic Fatigue Syndrome (CFS), major depression & in healthy volunteers

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Urinary free cortisol excretion (UFC) was compared in 21

patients with chronic fatigue syndrome (CFS), in 10

melancholic depressives and in 15 healthy controls. Patients

with depression had UFC values which were significantly higher

than healthy comparison subjects, whereas UFC excretion of CFS

patients was significantly lower than the comparison group.

These findings are in keeping with currently held hypotheses

of hyperactivity and hypoactivity of the

hypothalamic-pituitary-adrenal (HPA) axis in depression and

chronic fatigue syndrome respectively. Five of the 21 CFS

patients had a co-morbid depressive illness. This sub-group

retained the profile of UFC excretion of those with CFS alone,

suggesting a different pathophysiological basis for depressive

symptoms in CFS.

1 Star2 Stars3 Stars4 Stars5 Stars (73 votes, average: 2.40 out of 5)
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