The 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011), held in Boston the week of Feb 27 through Mar 2, included presentations on XMRV and chronic fatigue syndrome.
A video released Mar 3 includes nine brief research presentations “XMRV: New Findings and Controversies,” plus a brief recap of key findings and, finally, an audience Q&A. The video is provided here: http://app2.capitalreach.com/esp1204/servlet/tc?c=10164&cn=retro&s=20445&&dp=player.jsp&e=13744&mediaType=podiumVideo (Give video time to load)
Among the questions raised: Is it likely that XMRV evolved in the lab from some virus combination that resulted in infected cell lines, and regardless of its origins, are lab staff who have worked with these cells becoming infected, and what diseases might be associated with XMRV?
A summary by CFIDS Assoc. Scientific Director Suzanne Vernon, PhD, is very useful given to the technical language used in the presentations – See www.cfids.org/xmrv/croi-2011-summary.asp
Following is a list of the brief reports & other webinar features.
• “Development of a GFP-indicator Cell Line for the Detection of XMRV” – KyeongEun Lee NCI-Frederick, MD, US
• “XMRV Induces a Nonproductive Infection in Human Lymphoid Tissue” – Marta Curriu Fndn irsiCaixa, Badalona, Spain
• “Presence of XMRV Sequences in B Cells Are Restricted by APOBEC” – Jorge Carrillo Fndn irsiCaixa, Barcelona, Spain
• “Single Copy and Single Genome Sequencing Assays to Detect XMRV in Human Blood Products” – Mary Kearney HIV Drug Resistance Prgm, NCI-Frederick, MD, US
• “Discordant XMRV Test Results and Non-reproducible Mouse Endogenous Retroviral Detection in an XMRV Prevalence Study” – Timothy Henrich Brigham and Women`s Hosp, Boston, MA, US and Harvard Med Sch, Boston, MA, US
• “Serologic and PCR Testing of Persons with CFS in the US Shows No Association with XMRV” – William Switzer CDC, Atlanta, GA, US
• “Extensive Genetic Recombination in the XMRV Genome” – William Switzer CDC, Atlanta, GA, US
• “Disease-associated XMRV Sequences Explained by Laboratory Contamination” – Stéphane Hué Univ Coll London, UK
• “Identification of a Novel Endogenous Murine Leukemia Virus as an XMRV Ancestor” Oya Cingoz Tufts Univ Sch of Med, Boston, MA, US
Recap of key points made in each presentation
Audience Q&A session.