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Vitamin B-12 may be more effective than nortriptyline in improving painful diabetic neuropathy. – Source: International Journal of Food Sciences and Nutrition, Feb 12, 2009

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[Note: nortriptyline is a tricyclic antidepressant prescribed for diabetic neuropathy.]

Introduction: Despite many therapeutic options, painful diabetic neuropathy is still a common and challenging complication of diabetes mellitus and is often resistant to treatment with current modalities.

Methods: In this randomized, single-blind clinical trial we compared the efficacy of parenteral vitamin B-12 and nortriptyline, for symptomatic improvement of pain, paresthesia [“pins and needles”], burning, freezing, stabbing and electrical sensation.

Changes in nerve conduction parameters of amplitude, duration and latency were also compared.

Results: One hundred patients (50 in each group) completed the study. After treatment, the pain score based on a visual analogue scale decreased 3.66 units in the vitamin B-12 group and 0.84 units in the nortriptyline group (P < 0.001).

Similarly, the paresthesia score decreased 2.98 units versus 1.06 units (P < 0.001).

The decrements of tingling sensation were 3.48 units versus 1.02 units (P < 0.001).

Changes in vibration, position, pinprick and nerve conduction parameters were not significant in two groups.

Conclusion: In conclusion, vitamin B-12 is more effective than nortriptyline for the treatment of symptomatic painful diabetic neuropathy.

Source: International Journal of Food Sciences and Nutrition, Feb 12, 2009. PMID: 19212856, by Talaiei A, Siavash M, Majidi H, Chehrei A. Department of Endocrinology, Arak University of Medical Sciences, Arak, Iran. [E-mail: talaiei.a@arakmu.ac.ir]

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2 thoughts on “Vitamin B-12 may be more effective than nortriptyline in improving painful diabetic neuropathy. – Source: International Journal of Food Sciences and Nutrition, Feb 12, 2009”

  1. baba@uus.no says:

    It would be wonderful if a non-toxic vitamin could replace a drug with side effects in treating neuropathic pain. Wanting to know more about dosage and admininistration of the vitamin B12 I tried to find the article. I searched in the International Journal of Food Sciences and Nutrition, and in medline, but did not find the original article!

  2. feathermelightly says:

    I couldn’t find the source either.

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