This integrative review evaluates research studies that investigated the association between vitamin D and mood disorders affecting women to determine whether further research comparing these variables is warranted. A literature search using CINAHL, PsycINFO, MEDLINE, and PubMed databases was conducted to locate peer-reviewed mood disorder research studies that measured serum 25-hydroxyvitamin D (25[OH]D) levels.
Four of six studies reviewed imparted significant results, with all four showing an association between low 25(OH)D levels and higher incidences of four mood disorders:
• Premenstrual syndrome,
• Seasonal affective disorder,
• Non-specified mood disorder,
• And major depressive disorder.
This review indicates a possible biochemical mechanism occurring between vitamin D and mood disorders affecting women, warranting further studies of these variables using rigorous methodologies.
Source: Journal of Midwifery and Women’s Health, Sep-Oct 2008; 53(5):440-6. PMID: 18761297, by Murphy PK, Wagner CL. Medical University of South Carolina, Charleston, South Carolina, USA. [E-mail: firstname.lastname@example.org]