We all belong to 1 of 3 gut microbe ‘types’ – not linked to nationality, diet, age, gender.

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Journal Abstract:

Enterotypes of the human gut microbiome Source: Nature, Apr 20, 2011

[Note: The full text of this article is fee based, but the Nature News site has published a summary of its implications: “Gut study divides people into three types.” Clearly the potential for new discoveries is enormous and may turn up associations with disease risk, as in ME/CFS subgroups that have been associated with enteroviruses.]

Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world.

By combining 22 newly sequenced fecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific.

We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.

This indicates further the existence of a limited number of well-balanced host–microbial symbiotic states that might respond differently to diet and drug intake.

The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis to understand microbial communities.

Although individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties.

For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers.

Source: Nature, Apr 20, 2011. Arumungam M, Raes J, and scores of other members of the international Metagenomics of the Human Intestinal Tract (MetaHIT) Consortium.

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One thought on “We all belong to 1 of 3 gut microbe ‘types’ – not linked to nationality, diet, age, gender.”

  1. Sandy10m says:

    For those of us who destroyed our probiotics with antibiotics (because of prescriptions for chronic infections over the years), the most HELPFUL thing would be for someone to take several healthy individuals and test what their probiotics look like. Culture those combinations, and produce a probiotic pill that allows us to duplicate those combinations. Right now I’m shooting in the dark trying to put back the ones I need. Should I use Acidophilus? Or Bifidus? Or Rhamnosus? And what about the good yeasts, like the Saccharomyces family? Too much guesswork! I’m sure there are healthy people out there with great probiotic balance, and some research into this could produce a probiotic pill with that magic combination that would help a great deal, in my opinion.

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