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What You Need to Know About Folate and B12

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You have probably figured out by now that supplements are not created equal. When your health depends on nutrient support, you want to be sure the vitamins you are taking are in a form your body can easily use.

Why all the buzz about Folate and B12?

Folate and B12 have risen in exposure and notoriety as more people are finding out that they have an MTHFR genetic polymorphism or in layman’s terms – defect.

MTHFR is the abbreviation for Methylenetetrahydrofolate reductase, an enzyme needed for many chemical reactions involving forms of the B-vitamin folate.

The MTHFR gene encodes the Methylenetetrahydrofolate reductase enzyme which enables the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (forms of the B-vitamin folate).

This domino effect continues on with the conversion of an amino acid called homocysteine to another amino acid called methionine, critical for a majority of body functions.

Defects in the MTHFR gene can pose a greater risk for cardiovascular disease, dementia, neural tube defects and cancer just to name a few.

Folate and B12 are dynamic duos when it comes to supporting those with MTHFR, however, even those without a polymorphism, generally lack levels necessary for optimal health.

Understand folate is commonly referred to as folic acid, however, folic acid is the synthetic version of folate. This is not the same as natural folate found in uncooked leafy greens or the same as L-methylfolate, the most active form found in our bodies.

Other risk factors for folate deficiency:i

  • Diet lacking green leafy vegetables
  • Chronic diseases
  • Decreased absorption in the gut
  • Pregnancy
  • Alcoholism
  • Certain medications

Other risk factors for B12 deficiency:ii

  • Diet lacking meat, poultry, shellfish, eggs, and dairy products
  • Inability to absorb vitamin B12, due to a lack of a protein called intrinsic factor, necessary for absorption.
  • Chronic diseases
  • Alcoholism
  • Certain medications

Better together

According to the American Journal of Public Health, one of the concerns with fortifying foods with folic acid is a delay in diagnosis of a vitamin B12 deficiency. This is because folic acid shares a metabolic pathway with vitamin B12, and the anemia associated with vitamin B12 deficiency can be resolved by increasing the intake of folic acid. Prolonged deficiency of vitamin B12 can result in neurological damage, which, if left untreated, can be disabling and irreversible.iii

Many people are deficient in B12 and a deficiency in B12 will reduce the efficacy of l-methylfolate (the active form of folate). Taking both B vitamins ensures a better outcome for those who are not sure if they are low in B12 or not.

The British Medical Journal reported neuropsychiatric disorders in approximately two-thirds of adult patients presenting with magaloblastic anaemia due to folate deficiency, which overlap considerably with those associated with anaemia due to vitamin B-12 deficiency.iv

It was also reported that in a prospective community based study of 370 healthy elderly Swedish subjects, folate or vitamin B-12 deficiency doubled the risk of subsequently developing Alzheimer’s disease.v

Individually both B vitamins are power players in the body, but with a dysfunctional MTHFR enzyme, it becomes necessary, in most cases, to supplement with both B12 and l-methylfolate for optimal health.

When dealing with suboptimal conversion processes, it is vital that B12 and folate are in their biologically active states and that the method of delivery ensures their safe arrival inside the cells.

The only supplement to meet these requirements is Optimal Liposomal Active B12 with L-5-MTHF by Seeking Health. It is the only Liposomal Active B12 with L-5-MTHF to use non-hydrogenated phosphatidylcholine for its delivery method into your system (not hydroxylated, hydrogenated, nor “essential” phospholipids). Studies show hydrogenated liposomes significantly increase bad cholesterol levels while natural non-hydrogenated phosphatidylcholine does not.*

A lozenge form of Active B12 and L-5-MTHF is also available as Active B12 Lozenge with L-5-MTHF containing 800 mcg of L-5-MTHF and 1,000 mcg of B12 as methylcobalamin and adenosylcobalamin. Lozenges can be useful when a lower dosage is desired as they can be broken into smaller pieces.

Key Benefits and Actions of Optimal Liposomal Active B12 with L-5-MTHF:

  • Supports formation of healthy red blood cells*
  • Supports energy production*
  • Supports nervous system function*
  • Supports cognitive function*
  • Supports homocysteine regulation*
  • Supports DNA repair*

Supplement Use

Place 40 drops (or about one dropperful) into 1 oz glass of water or juice or place directly into the mouth and swallow. Do not take within 15 minutes of meals. Use as directed by your physician.

Reprinted with kind permission of Seeking Health


iLinus Pauling Institute
iiMedline Plus
iiiAmerican Journal of Public Health
ivBritish Medical Journal
vBritish Medical Journal

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One thought on “What You Need to Know About Folate and B12”

  1. mangove says:

    It is amazing how complex nutritional supplementation can be, love all this research!

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