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Much has been learned about
Lyme disease over the past several years, but much remains to be learned. Careful clinical observation has led to elucidation of the natural history of this
disease, and further clinical observations are needed to unravel the remaining areas of uncertainty. It is by no means clear that all the symptoms attributed to
Lyme disease today actually represent true manifestations of Borrelia burgdorferi infection or that patients with well-documented
Lyme disease whose symptoms do not respond to antibiotic therapy have persistent infection. Immunologically mediated mechanisms may be responsible for the chronic
disease manifestations that seem so resistant to antibiotics. Uncovering answers to these questions requires the close collaboration of astute practicing physicians and biomedical scientists working together for their patients’ benefit.