Lyme disease or Chronic Erythema Migrans whose first clinical description was made by Afzelius in 1908, and its causative agent the spirochete Borrelia Burgdorferi was discovered 73 years later by Willy Burgorfer in 1981. Lyme disease is spread by a tick bite of the family Ixodidae, Ixodes scapularis and many others.
Among the numerous species described, Borrelia Burgdorferi is disseminated mainly in the United States, Borrelia garinii and Borrelia Afzelii in Europe and Asia. In addition to producing skin lesions in infected people, and multi-organ side effects, the spirochete is able to reach the human brain and could produce dementia, Alzheimer’s, Parkinson’s and Autism.
In this investigation we will make a chronological description of the events that lead to neuronal involvement. Just as the spirochete of syphilis, Treponema pallidum, produces neurosyphilis in its tertiary stage, so also Borrelia is able to reach the brain, and produce collateral damage, a term called neuroborreliosis, and among its most lethal effects may cause dementia, Alzheimer’s, Parkinson’s and Autism and hence the so-called post-treatment syndrome of Lyme disease.
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This is an excellent article worth reading in full. It documents the history of Lyme discovery and research with very useful links to published papers.
- Lyme “neuroborreliosis” was not born in the 80s when it began to be mentioned in scientific studies after its causative agent, the Borrelia Burgdorferi was discovered by Willy Burgoderfer in 1981 and its presence in the human brain was later confirmed. He was born in 1922 when the French Garin and Bujadoux described for the first time the meningoradiculitis lymphocytic with its neurological manifestations.
- We demonstrate chronologically and scientifically that Borrelia Burgdorferi and its species can conquer the human brain and produce dementia, Parkinson’s, Alzheimer’s and Autism.
- Unlike Treponema pallidum, which only in the tertiary stage of syphilis is when it produces dementia (neurosyphilis); Borrelia Burgdorferi (Lyme) in its secondary and tertiary stage produces neuropsychiatric manifestations (neuroborreliosis).
- Lyme disease can present as pure neurological forms, without the presence of Erythema Chronicum Migrans (ECM); this fact is what in many cases makes the diagnosis difficult.
- Several highly specific diagnostic tests appeared to detect Borrelia Burgdorferi, even surpassing those proposed by the CDC.
- The World Health Organization(WHO) recognized the code “Lyme Neuroborreliosis”, “Dementia due to Lyme” this year of 2018 in the ICD-11 and the “demyelination of the central nervous system due to Lyme borreliosis”
- Clinical diseases not recognized: “Alzheimer due to Lyme”, “Parkinson due to Lyme”, but assuming that “dementia” is a common symptom of Alzheimer’s, its tacit recognition is understood; like the case of Parkinson’s, because the demyelination of the central nervous system and the chronic infection of the brain by Borrelia species can cause symptoms of Parkinsonism. Also the “Autism due to Lyme” was not recognized but like the previously described, it is supposed to be included in the term “neuroborreliosis due to Lyme”
- The Post-Treatment Lyme Disease Syndrome (PTLDS), was not recognized by the WHO; it was extensively reviewed in this research and which was described more than 20 years ago, will be the subject of a forthcoming investigation.
- Finally, the Lyme disease, now it is not only a dermatological disease, is a neuropsychiatric illness that can easy destroy your brain, if it is not detected and treated at time.
If we include Alzheimer’s disease, Parkinson’s disease and Autism within the spectrum “Lyme neuroborreliosis” code, only Post-Treatment Lyme Disease Syndrome (PTLDS) will be left out in this investigation.
Joanne Drayson was bitten by a tick whilst walking her dog in the woods in Guildford, UK in 2003 and had two further tick bites in 2005. She developed Erythema migrans rashes on all three bites but did not know the significance at that time of the rashes nor did the doctor she saw in 2005. She became sick with a summer flu unlike any other she had ever experienced and although that passed within a week, it left her with weakness in her upper arms and upper legs, and joint pain which migrated throughout her body, affecting every joint. It took 5 doctors, 3 rheumatologists and 4 years for her to be diagnosd with Lyme disease, after previous diagnoses of Fibromyalgia, ME/CFS, Musculoskeletal Disease and Polymyalgia Rheumatica, for which she was given 20 months of high dose steroids. Joanne was retired on ill Health Grounds from the Civil Service. She significantly regained her health after long- term combination pulsed antibiotic therapy. Fifteen years after her diagnosis she still occasionally relapses but responds well to a short course of antibiotics. She now maintains a blog called: https://lookingatlyme.blogspot.com.