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Lyme disease: resolution of a serous retinal detachment and chorioretinal folds after antibiotic therapy.

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Ocular manifestations of
Lyme disease are uncommon. There has not been a documented case of serous retinal detachment and chorioretinal folds because of
Lyme disease that have resolved after only antibiotic treatment.


A 69-year-old white man with a history of recent tick bites presented with a gradual decrease in visual acuity in the left eye. Initial visual acuity was 3/200 in the left eye. Examination revealed an inferior, serous, macula-off retinal detachment. Chorioretinal folds were also noted.
Lyme screening antibody test (enzyme-linked immunosorbent assay) was positive and a confirmatory Western blot was immunoglobulin M negative and immunoglobulin G positive.


Oral amoxicillin (500 mg 3 times daily for 2 weeks) was given followed by intravenous ceftriaxone (2 g daily for 4 weeks). After two weeks of ceftriaxone, fundus examination and ultrasonography showed complete reattachment of the macula and periphery, and only mild residual chorioretinal folds remained on fluorescein angiogram.


We suggest that Borrelia burgdorferi infection led to choroidal inflammation with secondary chorioretinal folds and a serous retinal detachment, which resolved with antibiotic therapy alone. This supports the suspicion of an intraocular infection, perhaps involving the choroid, as opposed to a secondary autoimmune reaction.

Retin Cases Brief Rep. 2012 Summer;6(3):232-4. doi: 10.1097/ICB.0b013e3182247783.

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