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Treatment of late Lyme borreliosis–randomised comparison of ceftriaxone and penicillin.

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Abstract

23 patients with clinically active late
Lyme disease were randomly assigned to intravenous treatment with either penicillin or ceftriaxone. Of the 10 treated with penicillin, 5 were judged treatment failures; of the 13 who received ceftriaxone, only 1 did not respond. An additional 31 patients were subsequently treated with ceftriaxone 4 g/day (n = 17) or 2 g/day (n = 14); success rates in both groups were comparable to those in the cohort randomised to ceftriaxone. Patients unresponsive to ceftriaxone were more likely to have received corticosteroid treatment.

Lancet. 1988 May 28;1(8596):1191-4. Clinical Trial; Comparative Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov’t

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