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The value of the DHEA-annexed vitamin C infusion treatment in the clinical control of CFS. II. Characterization of Chronic Fatigue Syndrome (CFS) patients with special reference to their response to a new vitamin C infusion treatment

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This study is a counterpart of the pilot study on the clinical

management of chronic fatigue syndrome (CFS) by the combined

use of the old (annex-free) and the new

(dehydro-epiandrosterone- annexed) vitamin C infusion

treatments with and without oral intake of erythromycin and

chloramphenicol. We were motivated to start this clinical

study by 2 reasons: i) we have made a success in the clinical

management of autoimmune disease and allergy by use of the

old megadose vitamin C infusion treatment, and we therefore

took up CFS as a good candidate for vitamin C infusion

treatment; ii)

In 1995, we received a total of 313 chronic

pneumonia patients whose clinical course showed a good fitness

to the criteria of CFS. We assessed the nature of the disease

by investigating the clinicoepidemiological aspect of our

patients on the one hand and the response of the disease to

both the old and new vitamin C infusion treatments with and

without the use of 2 antibiotics on the other hand. Results

are summarized as follows: a) the analysis of the medical

records of our outpatients revealed that chronic type

pneumonia epidemic in Nagoya Japan, with its onset of January

1995, showed no sign of its extinction by the end of May

1996. The patient population contained no patients under 15

years of age, and showed a distinct female predominance in

the patient number (207 females versus 106 males). In 1995,

we also experienced a simple cold epidemic with its onset of

January 1995 (162 males and 224 females). The majority of

simple cold patients were under 25 years of age in both

sexes. b)

A chronic type pneumonia patient was distinguished

from a simple cold patient in 2 respects: firstly the former

required prolonged medical care (over 1 month) resulting in

an incomplete cure and return to medical care upon the

recurrence of disease, whereas the latter required short-term

medical care (mostly within 1 week) ending up with complete

cure. Secondly, the former required the long term use of 2

antibiotics (erythromycin and chloramphenicol) together with

regular practice of the old and new vitamin C infusion

treatments for disease control, whereas the latter recovered

from the disease after the short time use of a set of

conventional cold remedies. c)

The clinical manifestations of

our chronic pneumonia patients showed good fitness to the

criteria of CFS. d) CFS was distinguished from autoimmune

disease-allergy complex by the method of clinical control:

the former required the long-term use of 2 antibiotics

together with regular practice of the old and new vitamin C

infusion treatments, whereas the latter was controllable by

the single use of the old vitamin C infusion treatment. e)

The combined use of the old and new vitamin C infusion

treatments rather than the single use of the old vitamin C

infusion treatment was more effective for the control of

CFS-a finding which suggests that deficient activities of

both endogenous glucocorticoid and endogenous androgen in a

CFS patient are somehow related to the genesis and further

development of CFS. f)

Evidence was available to indicate

that the sole use of the new vitamin C infusion treatment may

induce a state of gonadal steroid excess together with

various other problems in the recipient. The maintenance of a

good balance between the old vitamin C infusion set

(glucocorticoid-inducer) and the new vitamin C infusion set

(inducer of both glucocorticoid and gonadal steroids) in

their use was of prime importance for the successful control

of CFS. g) The historical significance of CFS epidemic in

1995, and in Nagoya-Japan, is discussed in the light of the

new infection concept.

Kodama M, Kodama T, Murakami M

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