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Ancient Tradition Meets Modern Science: The Result Is Intensive Immune System Support

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Immune System Support

With the fall and winter months rapidly approaching, the regular cold and flu season will soon be upon us yet again. When you combine that with various parts of the country reopening and children and young adults returning to school and college, it’s clear the health of your immune system continues to be vitally important.

Learn how you can support your immune system through these upcoming months with CV ACUTE, a trio of plant-based compounds that have been studied for their immune-boosting potential.

The Immune-Boosting Ingredients of CV ACUTE

A combination of extracts from the forsythia, honeysuckle, and Baikal skullcap plants creates a powerful phytopharmaceutical to reduce inflammation and strengthen the immune system.

This blend of extracts is known as SHL (Shuanghuanglian) in traditional Chinese medicine (TCM). A systematic review published in Evidenced-Based Complementary and Alternative Medicine in March 2013 found that SHL reduced fever, nasal congestion, cough, and sore throat in cases of acute upper respiratory tract infections.

Furthermore, a recent analysis published in the European Journal of Integrative Medicine in August 2020 found that SHL contains several anti-viral and anti-inflammatory compounds with therapeutic potential.

Let’s take a more in-depth look into the individual ingredients that make up CV ACUTE.

1. Forsythia

Forsythia (Forsythia suspensa) is a flowering plant that belongs to the family Oleaceae; TCM healing practices have used forsythia for over 4,000 years. Traditionally, forsythia has been used to clear out “heat” in the body, which manifests as fever, inflammation, and rapid heartbeat.

In modern research, the fruits of the forsythia plant have been studied for their anti-inflammatory properties, including the ability to inhibit the production of the pro-inflammatory compounds tumor necrosis factor-α (TNF-α) and COX-2.

Forsythia benefits the immune system by reducing mast cell degranulation, a cellular process that leads to histamine release, which is responsible for allergic responses, congestion, and nasal airway obstruction.

Also, forsythia inhibits interleukin-4 (IL-4) and IL-6 synthesis and increases Nrf2 activity. IL-4 is one of the cytokines involved with allergy-related inflammation, and Nrf2 is a crucial regulator of the body’s antioxidant pathways.

Some of the bioactive compounds in forsythia that produce these beneficial effects include saponins, triterpenoids, flavonoids, and lignans.

2. Honeysuckle Extract

The sweet and fragrant flowers of the honeysuckle plant (Lonicera japonica), which is native to eastern Asia, contain many molecules that provide anti-inflammatory and antioxidant functions. These include flavonoids, iridoids, saponins, volatile oils, and the phenolic acid compounds, chlorogenic and caffeic acid.

Honeysuckle modulates the immune system by inhibiting pro-inflammatory cytokines, including TNF-α and interleukin-1β (IL-1β), as well as reducing levels of harmful free radicals and reactive oxygen species.

In a study published in Scientific Reports in April 2017, researchers looked at the antiviral activity of chlorogenic acid, found in high amounts in honeysuckle. They found that chlorogenic acid blocked the release of common flu virus particles in cellular studies.

3. Baikal Skullcap

The root of Baikal skullcap (Scutellaria baicalensis) is the third and final phytopharmaceutical found in CV ACUTE. Also known as Chinese skullcap, this flowering plant has antibacterial, antiviral, antioxidant, detoxifying, and neuroprotective properties.

While there are dozens of bioactive compounds present in Baikal skullcap, the flavones baicalin and baicalein provide much of its health benefits. In an October 2016 study published in Scientific Reports, baicalin, extracted from Baikal skullcap and given to mice, blocked infection from respiratory syncytial virus (RSV), an acute respiratory tract infection that commonly affects young children.

How to Take CV ACUTE

CV ACUTE comes in liquid form; the plant extracts are mixed with glycerin, purified water, and a natural berry flavor. The recommended dosage for adults is two servings, three times per day, and one serving, three times per day for adolescents aged 10 to 18. A serving size is one teaspoon of the liquid.

Consult your doctor before starting the use of this product if you are taking other medications. This product is not recommended for young children or use during pregnancy or lactation. Discontinue use and consult your doctor if adverse reactions occur.

Your Takeaway

CV ACUTE is a powerful trio of forsythia, honeysuckle, and Baikal skullcap. These plant extracts are studied for their ability to modulate the immune system, reduce inflammation, and provide antibacterial and antiviral benefits. Consider CV ACUTE to support your immune system as the flu season approaches, and other viral challenges continue to remain a risk.


Cambria Glosz - Immune System SupportCambria Glosz is a Registered Dietitian and health writer with her Master’s degree in Nutrition from Cal Poly in San Luis Obispo. She spends her spare time exploring San Diego and posting recipes on her food and nutrition blog, Veggies Then Wine.


 

References:

Ding Y, Cao Z, Cao L, Ding G, Wang Z, Xiao W. Antiviral activity of chlorogenic acid against influenza A (H1N1/H3N2) virus and its inhibition of neuraminidase. Sci Rep. 2017;7:45723. Published 2017 Apr 10. doi:10.1038/srep45723

Kwon SH, Ma SX, Hong SI, Lee SY, Jang CG. Lonicera japonica THUNB. Extract Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses by Suppressing NF-κB Signaling in BV-2 Microglial Cells. J Med Food. 2015;18(7):762-775. doi:10.1089/jmf.2014.3341

Lee JJ, Kim KH, Kim EJ, et al. Anti-inflammatory activity of the decoction of Forsythia suspensa (Thunb.) Vahl is related to Nrf2 and A20. J Ethnopharmacol. 2018;227:97-104. doi:10.1016/j.jep.2018.08.027

Muluye RA, Bian Y, Alemu PN. Anti-inflammatory and Antimicrobial Effects of Heat-Clearing Chinese Herbs: A Current Review. J Tradit Complement Med. 2014;4(2):93-98. doi:10.4103/2225-4110.126635

Shang X, Pan H, Li M, Miao X, Ding H. Lonicera japonica Thunb.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. J Ethnopharmacol. 2011;138(1):1-21. doi:10.1016/j.jep.2011.08.016

Shi H, Ren K, Lv B, et al. Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice. Sci Rep. 2016;6:35851. Published 2016 Oct 21. doi:10.1038/srep35851

Zhang H, Chen Q, Zhou W, et al. Chinese medicine injection shuanghuanglian for treatment of acute upper respiratory tract infection: a systematic review of randomized controlled trials. Evid Based Complement Alternat Med. 2013. doi:10.1155/2013/987326

Zhao Q, Chen XY, Martin C. Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants. Sci Bull (Beijing). 2016;61(18):1391-1398. doi:10.1007/s11434-016-1136-5

Zhuang Z, Wen J, Zhang L, et al. Can network pharmacology identify the anti-virus and anti-inflammatory activities of Shuanghuanglian oral liquid used in Chinese medicine for respiratory tract infection?. Eur J Integr Med. 2020;37:101139. doi:10.1016/j.eujim.2020.101139

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