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Clinical correlates of infection with human herpesvirus-6

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Human herpesvirus-6 is a lymphotropic virus which infects

susceptible individuals during the first year of life and

usually causes life-long latency. In a variable percentage

primary infections are followed by a short acute disease,

exanthema subitum. Older individuals may suffer from

infectious mononucleosis-like illnesses or from

Kikuchi-Fujimoto’s disease. In addition, there is a fairly

wide spectrum of lymphoid and hematopoietic diseases or

autoimmune disorders, which are associated with elevated

titers of HHV-6 antibody, and from which replicating virus may

be isolated. Such diseases include atypical polyclonal

lymphoproliferation, Hodgkin’s disease, chronic fatigue

syndrome and systemic lupus erythematosus. The present article

reviews the current knowledge of such associations.

Krueger GR, Klueppelberg U, Hoffmann A, Ablashi DV

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