Tetramethoxyluteolin for the treatment of neurodegenerative diseases

The natural flavonoids luteolin and tetramethoxyluteolin have neuroprotective actions
1 Star2 Stars3 Stars4 Stars5 Stars (2 votes, average: 3.50 out of 5)


Background: Most neurodegenerative and other brain disorders, especially Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and autism spectrum disorder (ASD) continue to elude objective biomarkers and effective treatments. Increasing evidence indicates that such diseases involve focal inflammation of the brain.

Objective: To review the role of cytokine-neuropeptide interactions in the pathogenesis of inflammation of the brain and the beneficial role of natural flavonoids.

Method: Medline search was conducted (2000-2017) for articles using the terms allergy, amygdala, atopy, autism, brain, chemokines, cytokines, hypothalamus, immunity, inflammation, mast cells, microglia, neurotensin, peptides, substance P, TNF.

Results: Neuropeptides and cytokine stimulation of mast cells and microglia can results in focal inflammation in the hypothalamus and amygdala, thus explaining most of the symptoms at least in ME/CFS and ASD. Some of the triggers may be corticotropin-releasing hormone (CRH), neurotensin (NT), and substance P (SP), which has synergistic action with IL-33. The natural flavonoids luteolin and tetramethoxyluteolin inhibit these processes and have neuroprotective actions. Tetramethoxyluteolin is also more metabolically stable and has greater oral absorption.

Conclusion: Inhibition of inflammatory processes unique to the brain with intranasal formulations of tetramethoxyluteolin could provide new possibilities for the understanding and treatment of neurodegenerative diseases.

Source: Theoharides TC, Tsilioni I. Tetramethoxyluteolin for the treatment of neurodegenerative diseases. Curr Top Med Chem. 2018 Nov 19. doi: 10.2174/1568026617666181119154247. [Epub ahead of print]


Related articles

Abstract: Prognosis of Chronic Fatigue [Syndrome] in a Community-Based Sample
Low levels of serum acylcarnitine in Chronic Fatigue Syndrome (CFS) & chronic hepatitis type C, but not seen in other diseases
Nurse led, home based self help treatment for patients in primary care with chronic fatigue syndrome: Randomized controlled trial – Source: British Medical Journal, Apr 23, 2010
Abstract:The Neuroendocrinology of Chronic Fatigue Syndrome and Fibromyalgia
Risk markers for both chronic fatigue and irritable bowel syndromes: A prospective case-control study in primary care – Source: Psychological Medicine, Apr 15, 2009
Vitamin D and pelvic floor disorders in women: Results from the National Health and Nutrition Examination Survey – Source: Obstetrics and Gynecology, April 2010.
1 Star2 Stars3 Stars4 Stars5 Stars (2 votes, average: 3.50 out of 5)

Leave a Reply