DescriptionCentrophenoxine is a cholinergic compound which is a derivative of Dimethylaminoethanol (DMAE) and pCA (para-chlorophenoxyacetic acid) (1). As a cholinergic, it increases levels of acetylcholine in the brain.
- Supports cognitive health in the elderly with age-related decline (ref)*
- May increase alertness and support memory (ref)*
- May increase concentration and focus (ref)*
Centrophenoxine is a subject of interest in the medical community but thus far, the amount of clinical trials in humans is not plentiful. Some of these human studies are referenced above.
The following references are examples of dynamics associated with Centrophenoxine through the animal model and may not be representative of the effects in the human body:
- Promotes antioxidant activity (ref)(ref)*
- Supports information recall in elderly animal subjects (ref)*
- May decrease lipofuscin (pigments related to aging) (ref)*
- Supports RNA synthesis (ref)*
Centrophenoxine Mode of Action
Centrophenoxine is an ester (or derivative) of DMAE (Dimethylaminoethanol) that has been modified with the addition of pCA (para-chlorophenoxyacetic acid) (1). In animal research, it has demonstrated that it increases the amount of choline in the brain, by working through the presynaptic adrenoceptors of cholinergic terminals (2).
A unique function of Centrophenoxine is the ability to reduce the age-related pigment lipofuscin (3). Lipofuscins are peroxidized unsaturated fatty acids that are yellow-brown in color and are deposited in aged tissues. The lipofuscins are a combination of transition metals and oxidized lipids which cause a peroxidation reaction that produces radicals. They are mostly found deposited in neurons and cardiac cells and are believed to clog the cellular lysosome, which is responsible for cleaning waste within the cells. The lysosome then cannot digest the materials and the lipofuscin substance remains in the cell and becomes a residual body trapped in the cells (4).
The reduction of lipofuscins is attributed to Centrophenoxine’s antioxidant activity. By raising the levels of antioxidant enzymes, increased antioxidants then scavenge the peroxidized lipofuscins. Increases in SOD (superoxide dismutase) and GSH-Per (glutathione peroxidase) were noted in animal brains after ingestion of centrophenoxine (3).
The age-related decline in mRNA synthesis is also improved through Centrophenoxine in animal research. Again, it is believed to be part of the anti-oxidant promotion that increases the synthesis of mRNA which decreases with age (5).
Centrophenoxine Side Effects and Toxicity
Side effects are usually mild and may include headache, nausea, dizziness, gastrointestinal symptoms, and mild stimulant effects (6)(7).
DO NOT USE if pregnant. Like DMAE, Centrophenoxine can produce birth defects (8).
Some adverse events during supplementation with DMAE have raised concerns and the possibility that the events were related to DMAE could not be excluded. Please consult your healthcare practitioner before beginning supplementation, or if you are taking any medications (9).
Centrophenoxine may interact with blood pressure and it is recommended that those with severely high blood pressure avoid this supplement (9).
Please see manufacturer for references.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.