Goldenseal Advanced Digestive Support, by Botanipharm, is a synergistic whole plant combination scientifically formulated to deliver maximum potency.

Goldenseal helps your body maintain comfortable digestion and controlled bowel movements. Hydrastis canadensis, or goldenseal, is a bitter herb whose beneficial effects on digestion were first shown to European Settlers by the Native Americans. Traditionally used for infections, digestive disorders, sore mouth, and wound healing, more than 3,000 scientific articles currently exist supporting the potential benefits of goldenseal and/or it primary alkaloid constituent, berberine. Modern science has discovered these effects can be attributed to a number of compounds found in the plant called alkaloids, the primary one being berberine. Besides the active compounds in goldenseal, the plant contains other constituents which act synergistically with the alkaloids to increase their potency and/or reduce any potential adverse effects. Another beneficial aspect of goldenseal is that it does not contribute to the emergence of drug resistant bacteria. One of the most often reported historical uses for goldenseal is for cases of bacterial induced diarrhea. All Goldenseal products by Botanipharm are organically grown and sustainably harvested. They do not contain any wild harvested ingredients. This item cannot be shipped internationally. We sincerely apologize for any inconvenience. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Individual results may vary.

Label Information

Supplement Facts
Serving Size: 1 Teaspoon
Servings Per Container: 24
Amount Per Serving%DV
Goldenseal leaf267 mg*
Goldenseal root267 mg*
*Daily Value Not Established

Bioactivity comparable to 24 mg of Berberine. Made in the USA. Certified organic.

  • Suggested Use:

    For general digestive support, use 1/4 to 1/2 teaspoon in 1 cup of water or juice 15 minutes before eating.

  • Storage: Store in a cool, dry place. Keep out of reach of children.
  • Contraindications: When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. Do not exceed recommended dose.
  • Other Ingredients: Organic alcohol and water.

Frequently Asked Questions

Answered directly by Botanipharm...

What if I am not sure if I have a parasite? Goldenseal can have a number of beneficial effects on body function particularly during times of digestive system imbalance. This imbalance can manifest its self in a number of ways including acid reflux, excessive gas and bloating, ulcers, diarrhea, and more. The causes can include poor eating habits, parasites, food allergies, and emotional stress. In many instances, it can be hard to pinpoint a specific cause. One of the beautiful things about goldenseal is that it is not a drug and therefore does not just address one particular disease or set of symptoms. Goldenseal is a natural food that provides broad spectrum support for the entire digestive system regardless of the underlying cause. How does goldenseal work? First, goldenseal is a bitter. Bitters are well known for their ability to stimulate digestive enzymes and improve the entire digestive process. For maximum effectiveness, goldenseal should be taken 10 to 15 minutes before meals. This will get the entire digestive system up and running before food is ingested. Secondly, goldenseal assists the body in maintaining healthy microbial populations in the digestive tract. In a balanced digestive tract there are millions of beneficial microbes that reside in the intestine and perform a number of essential functions. However, food and/or water borne microbes that are not friendly to the digestive tract can seriously upset that balance. Our laboratory studies, as well as those of others, have shown that goldenseal creates an environment that is hostile to pathogenic organisms such as Staph., E. coli, Candida, and Giardia while having little to no effect on “friendly” organisms such as Lactobacillus acidophilus. In fact, our studies indicated that at eight times the concentration required to kill Staph., there was no inhibition of L. acidophilus. Thirdly, goldenseal has potent anti-inflammatory properties that soothe inflamed digestive tract linings and regulate the excessive mucosal secretions that result in diarrhea. How much Goldenseal Advanced Digestive Support should I use and how long does it take to see any effect? That depends on what type of digestive imbalance you are dealing with. For poor digestion and acid reflux issues, one teaspoon mixed with water or juice 10 to 15 minutes before meals seems to work well. Parasites can be an issue after traveling to a foreign country or to areas where sanitation is less than ideal. If you suspect a parasitic infestation, the approach is more proactive. We suggest a serving size based on body weight equivalent to 1 teaspoon per 25 pounds per day split into at least two servings daily for a minimum of four days. For example, an average size person weighing 150 to 175 pounds would need six teaspoons or two tablespoons per day. Those servings would be consumed one tablespoon in the morning and a second tablespoon in the evening for four days. You would need a 4 ounce bottle. There is a complete weight/serving size chart on the webpage. Many customers report significant improvement after the first couple of days however, Giardia and similar parasites can be very difficult to completely eliminate due to the fact that only live organisms will be eliminated, reproductive cysts will not. This is true for conventional drug treatments as well. Therefore, it is often necessary to repeat the regime outlined above a second time approximately 30 days after the first. This second round will eliminate any new organisms that may have “hatched” after the first round but before they are mature enough to reproduce again. Inflammatory bowel issues require a protocol similar to the one above except that a maintenance serving of one teaspoon in the morning and one teaspoon in the evening is maintained until the issues are resolved. How long can goldenseal be taken? Some have expressed concern that goldenseal shouldn’t be taken for more than two weeks at a time. That precaution is based on the assumption that goldenseal works like antibiotic drugs, indiscriminately killing good and bad organisms alike. Recent studies indicate this is a false assumption and in fact, it is likely that the exact opposite is true, as mentioned above, our data indicates goldenseal provides a protective effect to friendly organisms such as L. acidophilus. Why should I use whole plant goldenseal instead of isolated berberine? While berberine is the primary active compound found in goldenseal, it is not the only one. There are multiple active compounds in goldenseal that work synergistically with berberine and each other to produce a balanced effect. An example, similar to conventional antibiotics, isolated berberine inhibits L. acidophilus (friendly bacteria) at the same concentration as Staph. (harmful bacteria). On the other hand, Goldenseal Advanced Digestive Support does not inhibit L. acidophilus at eight times the concentration required to inhibit Staph. even though the natural product contains almost twice as much berberine. Clearly, the whole plant product offers a protective effect to beneficial bacteria. Another example, as a part of our USDA and NIH funded research, we observed a peculiar attribute of goldenseal leaf, there was no difference between the concentration required to inhibit normal “wild” type Staph. and the concentration required to inhibit Multiple Drug Resistant (MDR) Staph. This was very interesting considering it required 32 times more ciprofloxacin to inhibit the MDR Staph than the “wild” type. Even more interesting was when ciprofloxacin was combined with goldenseal leaf extract the MDR Staph was no longer “resistant”. Our chemistry collaborators at the University of Illinois, Chicago and Ohio State University indentified a certain group of compounds in goldenseal leaf that had no antimicrobial effect when used alone but, when combined with the berberine and other active compounds in goldenseal, these newly found compounds increased the active compound’s effectiveness by as much as 5,000 times!! Using isolated berberine is similar to listening to Beethoven’s Fifth Symphony and only hearing the brass section. You get the gist of the music but you just know something is missing. How were you able to do all this research? Our leadership in the area of organic medicinal plant cultivation and processing technology has been recognized through a series of eight Small Business Innovation Research awards from USDA and the National Institutes of Health National Center for Complementary and Alternative Medicine over the past 14 years. These awards culminated in the development of goldenseal products suitable for use in NIH funded human clinical studies specifically focused on digestive tract effect. Even though we are a small family operated farm, these awards have allowed us to foster relationships with more than 30 researchers at seven major research institutions and access to analytical equipment rivaling major pharmaceutical companies. Goldenseal Advanced Digestive Support was specifically developed for use in NIH funded human clinical studies. It is, quite simply, the most thoroughly tested and documented goldenseal product on the market, produced with the attention to quality that only comes from a family run operation.