Doctor’s Best Glucosamine/Chondroitin/MSM featuring OptiMSM supports joint structure, function and comfort. It is a potent combination of three clinically proven, purified ingredients that help build the cushy cartilage that serves as a shock absorber for your joints.

Glucosamine sulfate is extracted from chitin, a long-chain polymer consisting of many glucosamine molecules linked together. Chitin forms structural frameworks in many living things, including aquatic crustaceans. Doctor’s Best glucosamine is purified and then sulfated and stabilized with potassium chloride. It is processed to remove residues of protein and impurities, yielding pure glucosamine sulfate as the final material. Chondroitin sulfate is a chemical in cartilage around joints in the body. Chondroitin sulfate is manufactured from bovine cartilage. Doctor’s Best uses chondroitin sulfate with a purity of 90 percent or greater. Quality assurance testing is performed using sophisticated laboratory analytical methods. MSM is an excellent dietary source of bioavailable organic sulfur. Doctor’s Best MSM features OptiMSM®, a highly purified form (99.9% pure) of methylsulfonylmethane (MSM). Since the amount of MSM found naturally in living materials is too small to be extracted, the MSM used for dietary supplements is synthesized. The makers of OptiMSM® developed a four-stage process to separate impurities including heavy metals and other contaminants and is 99.9% pure MSM. Each batch exceeds the United States Pharmacopeia (USP) monograph standards for MSM, and is validated by testing in independent laboratories. Articular cartilage is a connective tissue composed of specialized cells (chondrocytes) embedded in a matrix of protein fibers (mostly collagen) and clusters of complex proteoglycan molecules that consist of a protein core with numerous side chains. These side chains, chiefly chondroitin sulfate and keratin sulfate, are long polysaccharide molecules called glycosaminoglycans. Chondroitin sulfate and the other glycosaminoglycans strongly attract water due to the negative charges of their sulfate groups. These negative charges also repel each other, creating spaces between glycosaminoglycan side chains where water can enter. This combination of solid and liquid gives cartilage a compressible quality that allows it to function as a shock absorber for joints. Glucosamine is a fundamental building block for proteoglycans and glycosaminoglycans. Glucosamine sulfate (GS) helps to maintain joint health through its ability to both act as a component of and stimulate formation of cartilage glycosaminoglycans and the hyaluronic acid backbone essential for the formation of cartilage proteoglycans. MSM contains two oxygen atoms and two methyl groups bound to a sulfur atom. As it donates its methyl groups, MSM enables important metabolic functions, including energy transduction and enzyme regulation. MSM’s use in joint stems from its organic sulfur support of the disulfide bonds that reinforce collagen fibers, a property that’s believed to promote connective tissue integrity and resilience. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Individual results may vary.

Label Information

Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 120
Amount Per Serving%DV
Chloride (from glucosamine sulfate 2KCI)84 mg2%
Sodium (from chondroitin sulfate sodium)28 mg1%
Potassium (from glucosamine sulfate 2KCI)91 mg3%
Glucosamine sulfate (2KCI)750 mg
Chondroitin sulfate (from chondroitin sulfate sodium)600 mg
Methylsulfonylmethane OptiMSM®500 mg
† % Daily Value (DV) not established.

OptiMSM® by Bergstrom Nutrition

  • Suggested Use:

    Take 2 capsules twice daily, with or without food or as recommended by a nutitionally-informed physician.

  • Storage: Store in a cool dry place. Keep out of reach of children.
  • Contraindications: When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. Do not exceed recommended dose.
  • Other Ingredients: Gelatin (capsule), cellulose, magnesium stearate (vegetable source). Contains shellfish (crab, shrimp, lobster, crayfish).
  • Contains No: GMO's, Gluten.

Frequently Asked Questions

How is OptiMSM purified? Through distillation. Is Chondroitin sodium-free? No, it does contain a small amount of sodium. Sodium must be added during processing. Glucosamine/Chondroitin/MSM contains just 14 mg of sodium per capsule. What if I'm allergic to sulfur, sulfa drugs or sulfites and sulfates? Can I take MSM? MSM is an organic substance that contains bioavailable sulfur. MSM contains about 34 percent elemental sulfur. 1000 mg of MSM contains about 340 milligrams of elemental sulfur. What is the difference between MSM and sulfur? MSM is an organic substance that contains bioavailable sulfur. MSM contains about 34 percent elemental sulfur. 1000 mg of MSM contains about 340 milligrams of elemental sulfur. What is your MSM made of? Is it natural or synthetic? It is synthetic. OptiMSM is made by converting DMSO (dimethylsufloxide) which is an organosulfur compound (organic compound containing sulfur), to DMSO2. All commercially available MSM is manufactured. Where is the MSM sourced? Doctor's Best uses OptiMSM, a premium trademarked form of MSM, made in the USA and certified for quality and consistency. What is the country of origin for Doctor's Best products? Doctor’s Best products are quality tested and manufactured in the United States using highly qualified cGMP manufacturers and raw material ingredients. Doctor’s Best sources raw materials from around the world and ingredients are subject to the intense testing and verification regardless of geography of origin.